Lipidomic signature of stroke recurrence after transient ischemic attack

Purroy, Francisco; Ois Santiago, Angel Javier; Jové, Mariona; Arque, Gloria; Sol, Joaquim; Mauri Capdevila, Gerard; Rodríguez-Campello, Ana; Pamplona, Reinald; Portero Otín, Manuel; Roquer, Jaume

doi:http://dx.doi.org/10.1038/s41598-023-40838-7

Lipidomic signature of stroke recurrence after transient ischemic attack

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Purroy F, Ois A, Jove M, Arque G, Sol J, Mauri-Capdevila G, et al. Lipidomic signature of stroke recurrence after transient ischemic attack. Sci Rep. 2023 Aug 22;13(1):13706. DOI: 10.1038/s41598-023-40838-7

Abstract

While TIA patients have transient symptoms, they should not be underestimated, as they could have an underlying pathology that may lead to a subsequent stroke: stroke recurrence (SR). Previously, it has been described the involvement of lipids in different vascular diseases. The aim of the current study was to perform a lipidomic analysis to identify differences in the lipidomic profile between patients with SR and patients without. Untargeted lipidomic analysis was performed in plasma samples of 460 consecutive TIA patients recruited < 24 h after the onset of symptoms. 37 (8%) patients suffered SR at 90 days. Lipidomic profiling disclosed 7 lipid species differentially expressed between groups: 5 triacylglycerides (TG), 1 diacylglyceride (DG), and 1 alkenyl-PE (plasmalogen) [specifically, TG(56:1), TG(63:0), TG(58:2), TG(50:5), TG(53:7, DG(38:5)) and PE(P-18:0/18:2)]. 6 of these 7 lipid species belonged to the glycerolipid family and a plasmalogen, pointing to bioenergetics pathways, as well as oxidative stress response. In this context, it was proposed the PE(P-18:0/18:2) as potential biomarker of SR condition.The observed changes in lipid patterns suggest pathophysiological mechanisms associated with lipid droplets metabolism and antioxidant protection that is translated to plasma level as consequence of a more intensive or high-risk ischemic condition related to SR.