Development and validation of a score to predict postoperative respiratory failure in a multicentre European cohort: A prospective, observational study.
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- dc.contributor.author Canet, Jaumeca
- dc.contributor.author Sabaté, Sergica
- dc.contributor.author Mazo, Valentínca
- dc.contributor.author Gallart Gallego, Lluísca
- dc.contributor.author Gama de Abreu, Marceloca
- dc.contributor.author Belda, Javierca
- dc.contributor.author Langeron, Olivierca
- dc.contributor.author Hoeft, Andreasca
- dc.contributor.author Pelosi, Paoloca
- dc.contributor.author PERISCOPE groupca
- dc.date.accessioned 2015-10-29T08:14:22Z
- dc.date.available 2016-07-31T02:00:04Z
- dc.date.issued 2015
- dc.description.abstract BACKGROUND: Postoperative respiratory failure (PRF) is the most frequent respiratory complication following surgery. OBJECTIVE:/nThe objective of this study was to build a clinically useful predictive model for the development of PRF. DESIGN: A prospective observational study of a multicentre cohort. SETTING: Sixty-three hospitals across Europe. PATIENTS: Patients undergoing any surgical procedure under general or regional anaesthesia during 7-day recruitment periods. MAIN OUTCOME MEASURES: Development of PRF within 5 days of surgery. PRF was defined by a partial pressure of oxygen in arterial blood (PaO2) less than 8 kPa or new onset oxyhaemoglobin saturation measured by pulse oximetry (SpO2) less than 90% whilst breathing room air that required conventional oxygen therapy, noninvasive or invasive mechanical ventilation./nRESULTS: PRF developed in 224 patients (4.2% of the 5384 patients studied). In-hospital mortality [95% confidence interval (95% CI)] was higher in patients who developed PRF [10.3% (6.3 to 14.3) vs. 0.4% (0.2 to 0.6)]. Regression modelling identified a predictive PRF score that includes seven independent risk factors: low preoperative SpO2; at least one preoperative respiratory symptom; preoperative chronic liver disease; history of congestive heart failure; open intrathoracic or upper abdominal surgery; surgical procedure lasting at least 2 h; and emergency surgery. The area under the receiver operating characteristic curve (c-statistic) was 0.82 (95% CI 0.79 to 0.85) and the Hosmer-Lemeshow goodness-of-fit statistic was 7.08 (P = 0.253). CONCLUSION: A risk score based on seven objective, easily assessed factors was able to predict which patients would develop PRF. The score could potentially facilitate preoperative risk assessment and management and provide a basis for testing interventions to improve outcomes.The study was registered at ClinicalTrials.gov (identifier NCT01346709).ca
- dc.description.sponsorship The PERISCOPE study was funded and supported through the European Society of Anaesthesiology’s Clinical Trials Network.
- dc.format.mimetype application/pdfca
- dc.identifier.citation Canet J, Sabaté S, Mazo V, Gallart L, Gamade Abreu M, Belda J. et al. Development and validation of a score to predict postoperative respiratory failure in a multicentre European cohort: A prospective, observational study. Eur J Anaesthesiol. 2015 Jul;32(7):458-70. doi: 10.1097/EJA.0000000000000223.ca
- dc.identifier.doi http://dx.doi.org/10.1097/EJA.0000000000000223
- dc.identifier.issn 0265-0215
- dc.identifier.uri http://hdl.handle.net/10230/24949
- dc.language.iso engca
- dc.publisher Lippincott, Williams & Wilkinsca
- dc.relation.ispartof European Journal of Anaesthesiology. 2015 Jul;32(7):458-70
- dc.rights This is a non-final version of an article published in final form in Canet J, Sabaté S, Mazo V, Gallart L, Gamade Abreu M, Belda J. et al. Development and validation of a score to predict postoperative respiratory failure in a multicentre European cohort: A prospective, observational study. Eur J Anaesthesiol. 2015 Jul;32(7):458-70. http://dx.doi.org/10.1097/EJA.0000000000000223.ca
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.subject.other Aparell respiratori -- Malaltiesca
- dc.subject.other Insuficiència respiratòriaca
- dc.title Development and validation of a score to predict postoperative respiratory failure in a multicentre European cohort: A prospective, observational study.ca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/acceptedVersionca