On the nature and function of organizers

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  • dc.contributor.author Martínez Arias, Alfonso
  • dc.contributor.author Steventon, Ben
  • dc.date.accessioned 2022-10-11T06:04:41Z
  • dc.date.available 2022-10-11T06:04:41Z
  • dc.date.issued 2018
  • dc.description.abstract Organizers, which comprise groups of cells with the ability to instruct adjacent cells into specific states, represent a key principle in developmental biology. The concept was first introduced by Spemann and Mangold, who showed that there is a cellular population in the newt embryo that elicits the development of a secondary axis from adjacent cells. Similar experiments in chicken and rabbit embryos subsequently revealed groups of cells with similar instructive potential. In birds and mammals, organizer activity is often associated with a structure known as the node, which has thus been considered a functional homologue of Spemann’s organizer. Here, we take an in-depth look at the structure and function of organizers across species and note that, whereas the amphibian organizer is a contingent collection of elements, each performing a specific function, the elements of organizers in other species are dispersed in time and space. This observation urges us to reconsider the universality and meaning of the organizer concept.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Martínez A, Steventon B. On the nature and function of organizers. Development. 2018 Mar;145(5):1-10. DOI: 10.1242/dev.159525
  • dc.identifier.doi http://dx.doi.org/10.1242/dev.159525
  • dc.identifier.issn 0950-1991
  • dc.identifier.uri http://hdl.handle.net/10230/54330
  • dc.language.iso eng
  • dc.publisher Company of Biologists
  • dc.relation.ispartof Development. 2018 Mar;145(5):1-10
  • dc.rights This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/3.0
  • dc.subject.keyword Axial organization
  • dc.subject.keyword Spemann
  • dc.subject.keyword Body plan
  • dc.subject.keyword Neural induction
  • dc.subject.keyword Organizer
  • dc.subject.keyword Vertebrate embryo
  • dc.title On the nature and function of organizers
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion