Evaluation of tobacco specific nitrosamines exposure by quantification of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in human hair of non-smokers
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- dc.contributor.author Pérez Ortuño, Raúl, 1976-ca
- dc.contributor.author Martínez-Sánchez, Jose M.ca
- dc.contributor.author Fu, Marcelaca
- dc.contributor.author Fernández, Esteveca
- dc.contributor.author Pascual, José A.ca
- dc.date.accessioned 2016-06-22T10:57:07Z
- dc.date.available 2016-06-22T10:57:07Z
- dc.date.issued 2016
- dc.description.abstract Chronic exposure to specific carcinogens present in secondhand smoke has been associated with different types of cancers. Hair is an ideal matrix to develop a proper biomarker as it absorbs substances in circulation and allows measuring their average concentration over long periods of time. A method was developed for the simultaneous quantification of nicotine, cotinine, NNN, NNK and NNAL in 20 mg human hair samples. Concentrations were significantly different depending on the declared exposure. This study shows for the first time that NNK is present in hair samples from non-smokers in concentrations much higher than any other tobacco specific nitrosamine. NNN could also be detected in samples from the most exposed non-smokers while, as previously reported, NNAL was undetectable. NNK correlates well with nicotine and cotinine (rsp = 0.774 and rsp = 0.792 respectively, p < 0.001 in both cases). However, NNN concentrations did not correlate with any of the other analytes. Ratios between NNK and nicotine show variability with different concentrations of NNK present in samples with similar nicotine values. NNK has proven to be the best marker of tobacco specific nitrosamines in hair. Monitoring NNK may provide a good estimation of cancer risk associated with exposure to secondhand smoke.ca
- dc.description.sponsorship This study was funded by Instituto de Salud Carlos III, Subdirección General de Evaluación y Fomento de la Investigación, PN I + D + I 2008-2011, co-funded by the European Regional Development Fund (FEDER), Government of Spain (Grants PI081339, PI081436 and RTICC RD12/0036/0053).
- dc.format.mimetype application/pdfca
- dc.identifier.citation Pérez-Ortuño R, Martínez-Sánchez JM, Fu M, Fernández E, Pascual JA. Evaluation of tobacco specific nitrosamines exposure by quantification of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in human hair of non-smokers. Sci Rep. 2016 Apr 26;6:25043. DOI: 10.1038/srep25043ca
- dc.identifier.doi http://dx.doi.org/10.1038/srep25043
- dc.identifier.issn 2045-2322
- dc.identifier.uri http://hdl.handle.net/10230/26955
- dc.language.iso engca
- dc.publisher Nature Publishing groupca
- dc.relation.ispartof Scientific Reports. 2016 Apr 26;6:25043
- dc.rights This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of thislicense, visit http://creativecommons.org/licenses/by/4.0/ca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/ca
- dc.subject.other Marcadors bioquímicsca
- dc.subject.other Tabac -- Efectes fisiològicsca
- dc.title Evaluation of tobacco specific nitrosamines exposure by quantification of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in human hair of non-smokersca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/publishedVersionca