Diagnostic accuracy of abdominal CT for locally advanced colon tumors: Can we really entrust certain decisions to the reliability of CT?
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- dc.contributor.author García Del Álamo Hernández, Yaiza
- dc.contributor.author Cano Valderrama, Óscar
- dc.contributor.author Cerdán-Santacruz, Carlos
- dc.contributor.author Pereira Pérez, Fernando
- dc.contributor.author Aldrey Cao, Inés
- dc.contributor.author Núñez Fernández, Sandra
- dc.contributor.author Álvarez Sarrado, Eduardo
- dc.contributor.author Obregón Reina, Rosángela
- dc.contributor.author Dujovne, Paula
- dc.contributor.author Taboada Ameneiro, María
- dc.contributor.author Ambrona Zafra, David
- dc.contributor.author Pérez Farré, Silvia
- dc.contributor.author Pascual Damieta, Marta
- dc.contributor.author Frago Montanuy, Ricardo
- dc.contributor.author Flor Lorente, Blas
- dc.contributor.author Biondo, Sebastiano
- dc.contributor.author Collaborative Group For The Study Of Metachronous Peritoneal Metastases Of pT Colon Cancer
- dc.date.accessioned 2024-10-23T06:09:26Z
- dc.date.available 2024-10-23T06:09:26Z
- dc.date.issued 2023
- dc.description.abstract Many different options of neoadjuvant treatments for advanced colon cancer are emerging. An accurate preoperative staging is crucial to select the most appropriate treatment option. A retrospective study was carried out on a national series of operated patients with T4 tumors. Considering the anatomo-pathological analysis of the surgical specimen as the gold standard, a diagnostic accuracy study was carried out on the variables T and N staging and the presence of peritoneal metastases (M1c). The parameters calculated were sensitivity, specificity, positive and negative predictive values, and positive and negative likelihood ratios, as well as the overall accuracy. A total of 50 centers participated in the study in which 1950 patients were analyzed. The sensitivity of CT for correct staging of T4 colon tumors was 57%. Regarding N staging, the overall accuracy was 63%, with a sensitivity of 64% and a specificity of 62%; however, the positive and negative likelihood ratios were 1.7 and 0.58, respectively. For the diagnosis of peritoneal metastases, the accuracy was 94.8%, with a sensitivity of 40% and specificity of 98%; in the case of peritoneal metastases, the positive and negative likelihood ratios were 24.4 and 0.61, respectively. The diagnostic accuracy of CT in the setting of advanced colon cancer still has some shortcomings for accurate diagnosis of stage T4, correct classification of lymph nodes, and preoperative detection of peritoneal metastases.
- dc.format.mimetype application/pdf
- dc.identifier.citation García Del Álamo Hernández Y, Cano-Valderrama Ó, Cerdán-Santacruz C, Pereira Pérez F, Aldrey Cao I, Núñez Fernández S, et al. Diagnostic accuracy of abdominal CT for locally advanced colon tumors: Can we really entrust certain decisions to the reliability of CT? J Clin Med. 2023 Oct 26;12(21):6764. DOI: 10.3390/jcm12216764
- dc.identifier.doi http://dx.doi.org/10.3390/jcm12216764
- dc.identifier.issn 2077-0383
- dc.identifier.uri http://hdl.handle.net/10230/68319
- dc.language.iso eng
- dc.publisher MDPI
- dc.relation.ispartof J Clin Med. 2023 Oct 26;12(21):6764
- dc.rights © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword CT staging
- dc.subject.keyword Advanced colon cancer
- dc.subject.keyword Diagnostic accuracy
- dc.title Diagnostic accuracy of abdominal CT for locally advanced colon tumors: Can we really entrust certain decisions to the reliability of CT?
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion