Cabut/dTIEG associates with the transcription factor Yorkie for growth control
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- dc.contributor.author Ruíz Romero, Marinaca
- dc.contributor.author Blanco, Enriqueca
- dc.contributor.author Paricio, Nuriaca
- dc.contributor.author Serras Rigalt, Florencica
- dc.contributor.author Corominas Guiu, Montserratca
- dc.date.accessioned 2015-11-10T15:12:09Z
- dc.date.available 2015-11-10T15:12:09Z
- dc.date.issued 2015
- dc.description.abstract The Drosophila transcription factor Cabut/dTIEG (Cbt) is a growth regulator, whose expression is modulated by different stimuli. Here, we determine Cbt association with chromatin and identify Yorkie (Yki), the transcriptional co-activator of the Hippo (Hpo) pathway as its partner. Cbt and Yki co-localize on common gene promoters, and the expression of target genes varies according to changes in Cbt levels. Down-regulation of Cbt suppresses the overgrowth phenotypes caused by mutations in expanded (ex) and yki overexpression, whereas its up-regulation promotes cell proliferation. Our results imply that Cbt is a novel partner of Yki that is required as a transcriptional co-activator in growth control.ca
- dc.format.mimetype application/pdfca
- dc.identifier.citation Ruiz-Romero M, Blanco E, Paricio N, Serras F, Corominas M. Cabut/dTIEG associates with the transcription factor Yorkie for growth control. EMBO Reports. 2015; 16(3): 362-369. DOI 10.15252/embr.201439193ca
- dc.identifier.doi http://dx.doi.org/10.15252/embr.201439193
- dc.identifier.issn 1469-221X
- dc.identifier.uri http://hdl.handle.net/10230/25037
- dc.language.iso engca
- dc.publisher EMBO Pressca
- dc.relation.ispartof EMBO Reports. 2015; 16(3): 362-369
- dc.rights © 2015 The Authors. Published under the terms of the CC BY NC ND 4.0 licenseca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/ca
- dc.subject.keyword Cabuten
- dc.subject.keyword dTIEGen
- dc.subject.keyword GAFen
- dc.subject.keyword Growthen
- dc.subject.keyword Yorkieen
- dc.subject.other Drosòfila -- Genèticaca
- dc.subject.other Regulació genèticaca
- dc.title Cabut/dTIEG associates with the transcription factor Yorkie for growth controlca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/publishedVersionca