Inexhaustible hair-cell regeneration in young and aged zebrafish
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- dc.contributor.author Pinto-Teixeira, Filipoca
- dc.contributor.author Viader Llargués, Oriolca
- dc.contributor.author Torres Mejı́a, Elenca
- dc.contributor.author Turan, Melissaca
- dc.contributor.author González Gualda, Estelaca
- dc.contributor.author Pola Morell, Lauraca
- dc.contributor.author López-Schier, Hernánca
- dc.date.accessioned 2015-11-11T19:10:02Z
- dc.date.available 2015-11-11T19:10:02Z
- dc.date.issued 2015
- dc.description.abstract Animals have evolved two general strategies to counter injury and maintain physiological function. The most prevalent is protection by isolating vital organs into body cavities. However, protection is not optimal for sensory systems because their external components need to be exposed to the environment to fulfill their receptive function. Thus, a common strategy to maintain sensory abilities against persistent environmental insult involves repair and regeneration. However, whether age or frequent injuries affect the regenerative capacity of sensory organs remains unknown. We have found that neuromasts of the zebrafish lateral line regenerate mechanosensory hair cells after recurrent severe injuries and in adulthood. Moreover, neuromasts can reverse transient imbalances of Notch signaling that result in defective organ proportions during repair. Our results reveal inextinguishable hair-cell regeneration in the lateral line, and suggest that the neuromast epithelium is formed by plastic territories that are maintained by continuous intercellular communication.ca
- dc.format.mimetype application/pdfca
- dc.identifier.citation Pinto-Teixeira F, Viader-Llargués O, Torres-Mejía E, Turan M, González-Gualda E, Pola-Morell L et al. Inexhaustible hair-cell regeneration in young and aged zebrafish. Biology open. 2015; 4(7): 903-909. DOI 10.1242/bio.012112ca
- dc.identifier.doi http://dx.doi.org/10.1242/bio.012112
- dc.identifier.issn 2046-6390
- dc.identifier.uri http://hdl.handle.net/10230/25056
- dc.language.iso engca
- dc.publisher Company of Biologists (J Experimental Biology)ca
- dc.relation.ispartof Biology open. 2015; 4(7): 903-909
- dc.rights © 2015. Published by The Company of Biologists Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.ca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.rights.uri http://creativecommons.org/licenses/by/3.0ca
- dc.subject.keyword Adulten
- dc.subject.keyword Hair cellsen
- dc.subject.keyword Lateral lineen
- dc.subject.keyword Notchen
- dc.subject.keyword Regenerationen
- dc.subject.keyword Self organizationen
- dc.subject.other Peixos zebra -- Òrgans sensorials -- Regeneracióca
- dc.subject.other Línia lateral (Zoologia) -- Regeneracióca
- dc.subject.other Cèl·lules acústiques -- Regeneracióca
- dc.title Inexhaustible hair-cell regeneration in young and aged zebrafishca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/publishedVersionca