Bipolar disorder and antibodies against the N-methyl-d-aspartate receptor: A gate to the involvement of autoimmunity in the pathophysiology of bipolar illness.

León Caballero, Jordi; Pacchiarotti, Isabella; Murru, Andrea; Valentí, M.; Colom, Francesc; Benach, B.; Pérez Solá, Victor; Dalmau, Josep; Vieta, Eduard

Bipolar disorder and antibodies against the N-methyl-d-aspartate receptor: A gate to the involvement of autoimmunity in the pathophysiology of bipolar illness.

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dc.contributor.author León Caballero, Jordica
dc.contributor.author Pacchiarotti, Isabellaca
dc.contributor.author Murru, Andreaca
dc.contributor.author Valentí, M.ca
dc.contributor.author Colom, Francescca
dc.contributor.author Benach, B.ca
dc.contributor.author Pérez Solá, Victorca
dc.contributor.author Dalmau, Josepca
dc.contributor.author Vieta, Eduardca
dc.date.accessioned 2015-11-17T11:16:29Z
dc.date.issued 2015
dc.description.abstract The high prevalence of comorbidity between bipolar disorder (BD) and other medical conditions, including autoimmune diseases, supports the hypothesis of the nature of BD as a biological illness category. Hence, an immune dysregulation process may play an important role in the development of at least certain subtypes of BD. Increasing evidence also suggests that the N-methyl-d-aspartate receptor (NMDAR) may be relevant in the pathophysiology of BD. A possible key mechanism underlying the physiopathology of certain autoimmune diseases that may present with affective symptoms might be the production of anti-NMDAR auto-antibodies (auto-Abs). The best characterized autoimmune anti-NMDAR disease is the anti-NMDAR encephalitis. It has been found that 4% of these patients present isolated, mostly affective, psychiatric manifestations during their illness. An interesting suggestion emerged from this overview is that the same mechanisms that trigger affective symptoms in patients with increased anti-NMDAR auto-Abs levels could be involved in the physiopathology of at least a subgroup of BD. Future studies are needed to characterize the relationship between anti-NMDAR auto-Abs and BD.ca
dc.description.sponsorship The authors ofthis report wouldlike to acknowledge the support of the Spanish Ministry of Economy and Competitiveness, Instituto de Salud Carlos III (CP08/00140 and PI 12/00910), CIBERSAM (Exp. CB07/ 09/0004), the Spanish Ministry of Education and the Comissionat per a Universitats i Recerca del DIUE de la Generalitat de Catalunya to the Bipolar Disorders Group (2014 SGR 398).
dc.format.mimetype application/pdfca
dc.identifier.citation León-Caballero J, Pacchiarotti I, Murru A, Valentí M, Colom F, Benach B. et al. Bipolar disorder and antibodies against the N-methyl-d-aspartate receptor: A gate to the involvement of autoimmunity in the pathophysiology of bipolar illness. Neurosci Biobehav Rev. 2015 Aug;55:403-12. doi: 10.1016/j.neubiorev.2015.05.012ca
dc.identifier.doi http://dx.doi.org/10.1016/j.neubiorev.2015.05.012
dc.identifier.issn 0149-7634
dc.identifier.uri http://hdl.handle.net/10230/25110
dc.language.iso engca
dc.publisher Elsevierca
dc.relation.ispartof Neuroscience & Biobehavioral Reviews. 2015 Aug;55:403-12
dc.rights.accessRights info:eu-repo/semantics/openAccessca
dc.subject.other Psicosi maniacodepressivaca
dc.subject.other Autoimmunitatca
dc.subject.other Depressió psíquicaca
dc.title Bipolar disorder and antibodies against the N-methyl-d-aspartate receptor: A gate to the involvement of autoimmunity in the pathophysiology of bipolar illness.ca
dc.type info:eu-repo/semantics/articleca
dc.type.version info:eu-repo/semantics/acceptedVersionca

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