Neonatal DNA methylation and childhood low prosocial behavior: An epigenome-wide association meta-analysis

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  • dc.contributor.author Luo, Mannan
  • dc.contributor.author Meehan, Alan J.
  • dc.contributor.author Walton, Esther
  • dc.contributor.author Röder, Stefan
  • dc.contributor.author Herberth, Gunda
  • dc.contributor.author Zenclussen, Ana C.
  • dc.contributor.author Cosín Tomàs, Marta
  • dc.contributor.author Sunyer Deu, Jordi
  • dc.contributor.author Mulder, Rosa H.
  • dc.contributor.author Cortes Hidalgo, Andrea P.
  • dc.contributor.author Bakermans-Kranenburg, Marian J.
  • dc.contributor.author Felix, Janine Frédérique
  • dc.contributor.author Relton, Caroline
  • dc.contributor.author Suderman, Matthew
  • dc.contributor.author Pappa, Irene
  • dc.contributor.author Kok, Rianne
  • dc.contributor.author Tiemeier, Henning
  • dc.contributor.author van IJzendoorn, Marinus H.
  • dc.contributor.author Barker, Edward D.
  • dc.contributor.author Cecil, Charlotte A. M.
  • dc.date.accessioned 2021-12-20T08:03:07Z
  • dc.date.available 2021-12-20T08:03:07Z
  • dc.date.issued 2021
  • dc.description.abstract Low prosocial behavior in childhood has been consistently linked to later psychopathology, with evidence supporting the influence of both genetic and environmental factors on its development. Although neonatal DNA methylation (DNAm) has been found to prospectively associate with a range of psychological traits in childhood, its potential role in prosocial development has yet to be investigated. This study investigated prospective associations between cord blood DNAm at birth and low prosocial behavior within and across four longitudinal birth cohorts from the Pregnancy And Childhood Epigenetics (PACE) Consortium. We examined (a) developmental trajectories of "chronic-low" versus "typical" prosocial behavior across childhood in a case-control design (N = 2,095), and (b) continuous "low prosocial" scores at comparable cross-cohort time-points (N = 2,121). Meta-analyses were performed to examine differentially methylated positions and regions. At the cohort-specific level, three CpGs were found to associate with chronic low prosocial behavior; however, none of these associations was replicated in another cohort. Meta-analysis revealed no epigenome-wide significant CpGs or regions. Overall, we found no evidence for associations between DNAm patterns at birth and low prosocial behavior across childhood. Findings highlight the importance of employing multi-cohort approaches to replicate epigenetic associations and reduce the risk of false positive discoveries.
  • dc.description.sponsorship The epigenetic studies in INMA were mainly funded by grants from Instituto de Salud Carlos III (Red INMA G03/176, CB06/02/0041, CP18/00018), Spanish Ministry of Health (FIS-PI04/1436, FIS-PI08/1151 including FEDER funds, FIS-PI11/00610, FIS-FEDER-PI06/0867, FIS-FEDER-PI03-1615), Generalitat de Catalunya-CIRIT 1999SGR 00241, Fundació La marató de TV3 (090430), EU Commission (261357-MeDALL: Mechanisms of the Development of ALLergy), and European Research Council (268479-BREATHE: BRain dEvelopment and Air polluTion ultrafine particles in scHool childrEn). MCT is funded by a Juan de la Cierva—Formación Postdoctoral Contract awarded by Ministry of Science and Innovation (FJC2018-036335-I). The 4, 7, and 11 year follow-up visits was funded by grants from Instituto de Salud Carlos III (Red INMA G03/176; CB06/02/0041; PI041436; PI081151 incl. FEDER funds; PI12/01890 incl. FEDER funds; CP13/00054 incl. FEDER funds; PI15/00118 incl. FEDER funds; CP16/00128 incl. FEDER funds; PI16/00118 incl. FEDER funds; PI16/00261 incl. FEDER funds; PI18/00547 incl. FEDER funds), CIBERESP, Generalitat de Catalunya-CIRIT 1999SGR 00241, Generalitat de Catalunya-AGAUR (2009 SGR 501, 2014 SGR 822), Fundació La marató de TV3 (090430), Spanish Ministry of Economy and Competitiveness (SAF2012-32991 incl. FEDER funds), Agence Nationale de Securite Sanitaire de l'Alimentation de l'Environnement et du Travail (1262C0010; EST-2016 RF-21), EU Commission (261357, 308333, 603794 and 634453). We acknowledge support from the Spanish Ministry of Science and Innovation and State Research Agency through the “Centro de Excelencia Severo Ochoa 2019-2023” Program (CEX2018-000806-S), and support from the Generalitat de Catalunya through the CERCA Program.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Luo M, Meehan AJ, Walton E, Röder S, Herberth G, Zenclussen AC, Cosín-Tomás M, Sunyer J, Mulder RH, Cortes Hidalgo AP, Bakermans-Kranenburg MJ, Felix JF, Relton C, Suderman M, Pappa I, Kok R, Tiemeier H, van IJzendoorn MH, Barker ED, Cecil CAM. Neonatal DNA methylation and childhood low prosocial behavior: An epigenome-wide association meta-analysis. Am J Med Genet B Neuropsychiatr Genet. 2021;186(4):228-41. DOI: 10.1002/ajmg.b.32862
  • dc.identifier.doi http://dx.doi.org/10.1002/ajmg.b.32862
  • dc.identifier.issn 1552-4841
  • dc.identifier.uri http://hdl.handle.net/10230/49256
  • dc.language.iso eng
  • dc.publisher Wiley
  • dc.relation.ispartof Am J Med Genet B Neuropsychiatr Genet. 2021;186(4):228-41
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/261357
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/308333
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/603794
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/634453
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/268479
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/669249
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/707404
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/848158
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2012-32991
  • dc.rights © 2021 The Authors. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.keyword DNA methylation
  • dc.subject.keyword Cord blood
  • dc.subject.keyword Epigenome-wide association study
  • dc.subject.keyword Meta-analysis
  • dc.subject.keyword Prosocial behavior
  • dc.title Neonatal DNA methylation and childhood low prosocial behavior: An epigenome-wide association meta-analysis
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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