Sex differences in motor and non-motor symptoms among Spanish patients with parkinson's disease
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- dc.contributor.author Santos García, Diego
- dc.contributor.author Puente Periz, Victor Manuel
- dc.contributor.author COPPADIS Study Group
- dc.date.accessioned 2024-04-29T07:21:18Z
- dc.date.available 2024-04-29T07:21:18Z
- dc.date.issued 2023
- dc.description.abstract Background and objective: Sex plays a role in Parkinson’s disease (PD) mechanisms. We analyzed sex difference manifestations among Spanish patients with PD. Patients and Methods: PD patients who were recruited from the Spanish cohort COPPADIS from January 2016 to November 2017 were included. A cross-sectional and a two-year follow-up analysis were conducted. Univariate analyses and general linear model repeated measure were used. Results: At baseline, data from 681 PD patients (mean age 62.54 ± 8.93) fit the criteria for analysis. Of them, 410 (60.2%) were males and 271 (39.8%) females. There were no differences between the groups in mean age (62.36 ± 8.73 vs. 62.8 ± 9.24; p = 0.297) or in the time from symptoms onset (5.66 ± 4.65 vs. 5.21 ± 4.11; p = 0.259). Symptoms such as depression (p < 0.0001), fatigue (p < 0.0001), and pain (p < 0.00001) were more frequent and/or severe in females, whereas other symptoms such as hypomimia (p < 0.0001), speech problems (p < 0.0001), rigidity (p < 0.0001), and hypersexuality (p < 0.0001) were more noted in males. Women received a lower levodopa equivalent daily dose (p = 0.002). Perception of quality of life was generally worse in females (PDQ-39, p = 0.002; EUROHIS-QOL8, p = 0.009). After the two-year follow-up, the NMS burden (Non-Motor Symptoms Scale total score) increased more significantly in males (p = 0.012) but the functional capacity (Schwab and England Activities of Daily Living Scale) was more impaired in females (p = 0.001). Conclusion: The present study demonstrates that there are important sex differences in PD. Long-term prospective comparative studies are needed.
- dc.format.mimetype application/pdf
- dc.identifier.citation Santos-García D, Laguna A, Hernández-Vara J, de Deus Fonticoba T, Cores Bartolomé C, Feal Painceiras MJ, et al. Sex differences in motor and non-Motor symptoms among Spanish patients with parkinson's disease. J Clin Med. 2023 Feb 7;12(4):1329. DOI: 10.3390/jcm12041329
- dc.identifier.doi http://dx.doi.org/10.3390/jcm12041329
- dc.identifier.issn 2077-0383
- dc.identifier.uri http://hdl.handle.net/10230/59927
- dc.language.iso eng
- dc.publisher MDPI
- dc.relation.ispartof J Clin Med. 2023 Feb 7;12(4):1329
- dc.rights © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Motor
- dc.subject.keyword Non-motor symptoms
- dc.subject.keyword Gender
- dc.subject.keyword Parkinson’s disease
- dc.subject.keyword Quality of life
- dc.subject.keyword Sex
- dc.title Sex differences in motor and non-motor symptoms among Spanish patients with parkinson's disease
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion