Genomes shed light on the secret life of Candida glabrata: not so asexual, not so commensal

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  • dc.contributor.author Gabaldón Estevan, Juan Antonio, 1973-
  • dc.contributor.author Fairhead, Cécile
  • dc.date.accessioned 2019-03-05T08:14:37Z
  • dc.date.available 2019-03-05T08:14:37Z
  • dc.date.issued 2019
  • dc.description.abstract Candida glabrata is an opportunistic yeast pathogen, whose incidence has increased over the last decades. Despite its genus name, this species is actually more closely related to the budding yeast Saccharomyces cerevisiae than to other Candida pathogens, such as Candida albicans. Hence, C. glabrata and C. albicans must have acquired the ability to infect humans independently, which is reflected in the use of different mechanism for virulence, and survival in the host. Yet, research on C. glabrata suffers from assumptions carried over from the more studied C. albicans. Regarding the adaptation of C. glabrata to the human host, the prejudice was that, just as C. albicans, C. glabrata is a natural human commensal that turns deadly when immune defenses weaken. It was also considered asexual, as no one has observed mating, diploids, or spores, despite great efforts. However, the recent analysis of whole genomes from globally distributed C. glabrata isolates have shaken these assumptions. C. glabrata seems to be only secondarily associated to humans, as indicated by a lack of co-evolution with its host, and genomic footprints of recombination shows compelling evidence that this yeast is able to have sex. Here, we discuss the implications of this and other recent findings and highlight the new questions opened by this change in paradigm.
  • dc.description.sponsorship TG group acknowledges support from the Spanish Ministry of Economy, Industry, and Competitiveness (MEIC) for the EMBL partnership, and Grants ‘Centro de Excelencia Severo Ochoa 2013–2017’ SEV-2012-0208, and BFU2015-67107 cofounded by European Regional Development Fund (ERDF); from the CERCA Programme / Generalitat de Catalunya; from the Catalan Research Agency (AGAUR) SGR857, and Grant from the European Union’s Horizon 2020 research and innovation programme under the Grant Agreement ERC-2016-724173 the Marie Sklodowska-Curie Grant Agreement no. H2020-MSCA-ITN-2014-642095. CF acknowledges support from the CNRS through the GDRI iGénolevures.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Gabaldón T, Fairhead C. Genomes shed light on the secret life of Candida glabrata: not so asexual, not so commensal. Curr Genet. 2019; 65(1):93-8. DOI: 10.1007/s00294-018-0867-z
  • dc.identifier.doi http://dx.doi.org/10.1007/s00294-018-0867-z
  • dc.identifier.issn 0172-8083
  • dc.identifier.uri http://hdl.handle.net/10230/36732
  • dc.language.iso eng
  • dc.publisher Springer
  • dc.relation.ispartof Current Genetics. 2019; 65(1):93-8
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SEV2012-0208
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BFU2015-67107
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/724173
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/642095
  • dc.rights © Springer-Verlag GmbH Germany, part of Springer Nature 2018. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.keyword Candida glabrata
  • dc.subject.keyword Candida
  • dc.subject.keyword Fungal pathogens
  • dc.subject.keyword Candidiasis
  • dc.subject.keyword Genome sequencing
  • dc.title Genomes shed light on the secret life of Candida glabrata: not so asexual, not so commensal
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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