FDG PET- CT SUVmax and IASLC/ATS/ERS histologic classification: a new profile of lung adenocarcinoma with prognostic value
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- dc.contributor.author Suárez-Piñera, Marina
- dc.contributor.author Belda, José
- dc.contributor.author Taus García, Álvaro
- dc.contributor.author Sánchez-Font, Albert
- dc.contributor.author Mestre-Fusco, Antoni
- dc.contributor.author Jiménez, Marcel
- dc.contributor.author Pijuan Andujar, Lara
- dc.date.accessioned 2019-02-25T08:51:44Z
- dc.date.available 2019-02-25T08:51:44Z
- dc.date.issued 2018
- dc.description.abstract Quantitative analysis of glucose consumption measured by maximum standardized uptake value (SUVmax) in lung adenocarcinoma (LA) remains in discussion and metabolic information provided by FDG-PET is not included in cancer staging. The first aim of this work was to evaluate the correlation between SUVmax and different histologic subtypes of LA. The second aim was to establish the correlation between SUVmax and TNM, genetic mutations and prognostic. Glucose consumption of primary tumor was quantified using SUVmax in 112 patients with histologically-confirmed LA. Specimens were classified according to the IASLC/ATS/ERS into in situ -AIS-, minimally invasive -MIA-, invasive (lepidic, papillary, acinar, solid and micropapillary) and invasive mucinous adenocarcinoma. Tumors were grouped according to three histological grades; low-grade: AIS, MIA, intermediate-grade: lepidic, acinar, papillary and high-grade: micropapillary, solid and mucinous. Comparisons between SUVmax and histologic subtypes were performed with Kruskal-Wallis followed by a Dunn's test. Overall (OS) and disease-free survival (DFS) were calculated. SUVmax was histologically-dependent (P<0.001): AIS 0.5±0.1, MIA 1.1±0.9 lepidic 3.3±3.1, acinar 8.6±6.7, papillary 3.9±5.1, micropapillary 4.9±3.4, solid 10.4±5.4 and invasive mucinous 2.7±1.2. SUVmax was associated with TNM stage in stage IA and IB. SUVmax was significantly lower in patients with K-RAS and EGFR mutation. Low SUVmax was associated with low-grade histology and with a higher OS and DSF compared to high SUVmax (intermediate and high-grade histology). SUVmax on FDG-PET is a powerful information in the presurgical evaluation of LA patients. It provides prognostic data and should be considered in the staging algorithm of patients with LA.
- dc.format.mimetype application/pdf
- dc.identifier.citation Suárez-Piñera M, Belda-Sanchis J, Taus A, Sánchez-Font A, Mestre-Fusco A, Jiménez M. et al. FDG PET- CT SUVmax and IASLC/ATS/ERS histologic classification: a new profile of lungadenocarcinoma with prognostic value. Am J Nucl Med Mol Imaging. 2018 Apr 25;8(2):100-109.
- dc.identifier.issn 2160-8407
- dc.identifier.uri http://hdl.handle.net/10230/36667
- dc.language.iso eng
- dc.publisher e-Century Publishing
- dc.relation.ispartof American Journal of Nuclear Medicine and Molecular Imaging. 2018 Apr 25;8(2):100-9
- dc.rights AJNMMI Copyright © 2018. Articles from American Journal of Nuclear Medicine and Molecular Imaging are provided here courtesy of e-Century Publishing Corporation
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.subject.keyword 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET)
- dc.subject.keyword Lung adenocarcinoma
- dc.subject.keyword Histologic classification
- dc.subject.keyword Maximum standardized uptake value (SUVmax)
- dc.subject.keyword Prognostic
- dc.subject.keyword Staging
- dc.title FDG PET- CT SUVmax and IASLC/ATS/ERS histologic classification: a new profile of lung adenocarcinoma with prognostic value
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion