Geometric diagrams of genomes: constructing a visual grammar for 3D genomics

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dc.contributor.authorMolins-Pitarch, Carla
dc.contributor.authorKhao, Jonathan
dc.contributor.authorBonet, Santiago
dc.contributor.authorJusticia, Yolanda
dc.contributor.authorAltube, Clementina
dc.contributor.authorGoodstadt, Mike N.
dc.contributor.authorRibot, Francesc
dc.contributor.authorLieberman Aiden, Erez
dc.contributor.authorNeretti, Nicola
dc.contributor.authorMcGill, Gaƫl G.
dc.contributor.authorMarti-Renom, Marc A.
dc.date.accessioned2025-10-09T05:48:24Z
dc.date.available2025-10-09T05:48:24Z
dc.date.issued2025
dc.description.abstractAdvances in the field of three-dimensional (3D) genomics have revealed an ever-expanding array of architectural features that were unknown only a few years ago. Just as ribbon diagrams integrate spatial and symbolic representation to communicate the shape of a protein, the representation of genomes in 3D space requires the development and use of new cartographic symbols and visual conventions. Here, we propose a conceptualized grammar that makes it easier to create visual 3D representations of genomes.
dc.description.sponsorshipThis project has received funding from the European Unionā€™s Horizon 2020 research and innovation programme under the Sklodowska-Curie grant agreement No 823327 to M.A.M-R. and F.R. M.A.M-R. also acknowledges support by the Spanish Ministerio de Ciencia e InnovaciĆ³n (PID2020-115696RB-I00 and PID2023-151484NB-I00). M.A.M-R., E.L.A., and N.N. acknowledge support by the National Human Genome Research Institute of the National Institutes of Health under Award Number RM1HG011016. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
dc.format.mimetypeapplication/pdf
dc.identifier.citationMolins-Pitarch C, Khao J, Bonet S, Justicia Y, Altube C, Goodstadt M, et al. Geometric diagrams of genomes: constructing a visual grammar for 3D genomics. Genome Biol. 2025 Jun 26;26(1):181. DOI: 10.1186/s13059-025-03646-y
dc.identifier.doihttp://dx.doi.org/10.1186/s13059-025-03646-y
dc.identifier.issn1474-7596
dc.identifier.urihttp://hdl.handle.net/10230/71440
dc.language.isoeng
dc.publisherBioMed Central
dc.relation.ispartofGenome biology. 2025 Jun 26;26(1):181
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/2PE/PID2020-115696RB-I00
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/3PE/PID2023-151484NB-I00
dc.rightsĀ© The Author(s) 2025. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.otherGenĆ²mica
dc.titleGeometric diagrams of genomes: constructing a visual grammar for 3D genomics
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion

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