Carotid atherosclerosis in virologically suppressed HIV patients: comparison with a healthy sample and prediction by cardiovascular risk equations

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• dc.contributor.author Saumoy, Maria
• dc.contributor.author Di Yacovo, Silvana
• dc.contributor.author Pérez, S.
• dc.contributor.author Sánchez Quesada, José Luis
• dc.contributor.author Valdivielso, Jose Manuel
• dc.contributor.author Subirana Cachinero, Isaac
• dc.contributor.author Imaz, Arkaitz
• dc.contributor.author Tiraboschi, Juan M.
• dc.contributor.author García, Benito
• dc.contributor.author Ordóñez Llanos, Jordi
• dc.contributor.author Benítez, Susana
• dc.contributor.author Podzamczer, Daniel
• dc.contributor.author Grau Magaña, Maria
• dc.date.accessioned 2021-09-17T07:37:41Z
• dc.date.issued 2021
• dc.description.abstract Objectives: To compare the prevalence of carotid atherosclerosis in virologically suppressed HIV patients with that of a community sample, and to evaluate the capacity of various cardiovascular risk (CVR) equations for predicting carotid atherosclerosis. Methods: This was a cross-sectional study with two randomly selected groups: HIV patients from an HIV unit and a control group drawn from the community. Participants were matched by age (30-80 years) and sex without history of cardiovascular disease. Carotid plaque, common carotid intima-media thickness (cc-IMT) and subclinical atherosclerosis (carotid plaque and/or cc-IMT > 75th percentile) were assessed by carotid ultrasound. The Systematic Coronary Risk Evaluation (SCORE), Framingham, REGICOR, reduced Data Collection on Adverse Effects of Anti-HIV Drugs (D:A:D), and COMVIH equations were applied, and their abilities to predict carotid plaque were compared using the area under the curve (AUC). Results: Each group included 379 subjects (77.8% men, age 49.7 years). Duration of antiretroviral therapy was 15.5 years. There were no differences between the groups for carotid plaque (HIV, 33.2%; control, 31.3%), mean cc-IMT (HIV, 0.63 mm; control, 0.61 mm) or subclinical atherosclerosis (HIV, 42.9%; control, 47.9%). Thymidine analogues were independently associated with subclinical atherosclerosis in HIV-infected patients. CVR equations revealed AUCs between 0.715 and 0.807 for prediction of carotid plaque; prediction was better in the control group and did not improve when HIV-adapted scales were used. Conclusions: The features of carotid atherosclerosis did not differ between the HIV-infected and the control group, although CVR equations were more predictive for carotid plaque in controls than in HIV-infected patients. HIV-specific equations did not improve prediction.
• dc.format.mimetype application/pdf
• dc.identifier.citation Saumoy M, Di Yacovo S, Pérez S, Sánchez-Quesada JL, Valdivielso JM, Subirana I, Imaz A, Tiraboschi JM, García B, Ordoñez-LLanos J, Benítez S, Podzamczer D, Grau M. Carotid atherosclerosis in virologically suppressed HIV patients: comparison with a healthy sample and prediction by cardiovascular risk equations. HIV Med. 2021;22(7):581-91. DOI: 10.1111/hiv.13093
• dc.identifier.doi http://dx.doi.org/10.1111/hiv.13093
• dc.identifier.issn 1464-2662
• dc.identifier.uri http://hdl.handle.net/10230/48477
• dc.language.iso eng
• dc.publisher Wiley
• dc.relation.ispartof HIV Med. 2021;22(7):581-91
• dc.rights This is the peer reviewed version of the following article: Saumoy M, Di Yacovo S, Pérez S, Sánchez-Quesada JL, Valdivielso JM, Subirana I, Imaz A, Tiraboschi JM, García B, Ordoñez-LLanos J, Benítez S, Podzamczer D, Grau M. Carotid atherosclerosis in virologically suppressed HIV patients: comparison with a healthy sample and prediction by cardiovascular risk equations. HIV Med. 2021;22(7):581-91. DOI: 10.1111/hiv.13093, which has been published in final form at http://dx.doi.org/10.1111/hiv.13093. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword HIV infection
• dc.subject.keyword Cardiovascular risk equations
• dc.subject.keyword Carotid intima-media thickness
• dc.subject.keyword Carotid plaque
• dc.subject.keyword Subclinical atherosclerosis
• dc.title Carotid atherosclerosis in virologically suppressed HIV patients: comparison with a healthy sample and prediction by cardiovascular risk equations
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion