Human DNA methylomes of neurodegenerative diseases show common epigenomic patterns
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- dc.contributor.author Sánchez Mut, Jose V.ca
- dc.contributor.author Heyn, Holgerca
- dc.contributor.author Vidal, Enriqueca
- dc.contributor.author Moran, Sebastianca
- dc.contributor.author Sayols, Sergica
- dc.contributor.author Delgado Morales, Raulca
- dc.contributor.author Schultz, Matthew D.ca
- dc.contributor.author Ansoleaga, Belénca
- dc.contributor.author García Esparcia, Paulaca
- dc.contributor.author Pons Espinal, Meritxell, 1986-ca
- dc.contributor.author Martínez de Lagrán Cabredo, Maríaca
- dc.contributor.author Dopazo, Jose M.ca
- dc.contributor.author Rábano, Albertoca
- dc.contributor.author Ávila, Jesúsca
- dc.contributor.author Dierssen, Maraca
- dc.contributor.author Lott, Ira T.ca
- dc.contributor.author Ferrer, Isidreca
- dc.contributor.author Ecker, Joseph R.ca
- dc.contributor.author Esteller, Manelca
- dc.date.accessioned 2016-06-03T14:38:50Z
- dc.date.available 2016-06-03T14:38:50Z
- dc.date.issued 2016
- dc.description.abstract Different neurodegenerative disorders often show similar lesions, such as the presence of amyloid plaques, TAU-neurotangles and synuclein inclusions. The genetically inherited forms are rare, so we wondered whether shared epigenetic aberrations, such as those affecting DNA methylation, might also exist. The studied samples were gray matter samples from the prefrontal cortex of control and neurodegenerative disease-associated cases. We performed the DNA methylation analyses of Alzheimer's disease, dementia with Lewy bodies, Parkinson's disease and Alzheimer-like neurodegenerative profile associated with Down's syndrome samples. The DNA methylation landscapes obtained show that neurodegenerative diseases share similar aberrant CpG methylation shifts targeting a defined gene set. Our findings suggest that neurodegenerative disorders might have similar pathogenetic mechanisms that subsequently evolve into different clinical entities. The identified aberrant DNA methylation changes can be used as biomarkers of the disorders and as potential new targets for the development of new therapies.ca
- dc.description.sponsorship This work was supported by the Human Frontiers Science Program (HFSP) Ref. RGP0018/2007-C, the European Community’s RGP0018/2007-C (FP7/2007-2013) under grant agreement PITN-GA-2009-238242—DISCHROM project and grant agreement 278486-DEVELAGE, the Instituto de Salud Carlos III—Ministerio de Sanidad y Consumo Proyecto FIS (Fondo Investigación Sanitaria, Spain) through the E-RARE EuroRETT network, Grants P50-AG16573, HD065160-01 and SAF2007-6-8, the Fondation Lejeune, Botin Foundation, Fundació Agrupació Premi Àmbit Gent Grant and the Cellex Foundation (Catalonia).
- dc.format.mimetype application/pdfca
- dc.identifier.citation Sanchez-Mut JV, Heyn H, Vidal E, Moran S, Sayols S, Delgado-Morales R et al. Human DNA methylomes of neurodegenerative diseases show common epigenomic patterns. Translational psychiatry. 2016; 6: e718. DOI 10.1038/tp.2015.214ca
- dc.identifier.doi http://dx.doi.org/10.1038/tp.2015.214
- dc.identifier.issn 2158-3188
- dc.identifier.uri http://hdl.handle.net/10230/26821
- dc.language.iso engca
- dc.publisher Nature Publishing Groupca
- dc.relation.ispartof Translational psychiatry. 2016; 6: e718
- dc.rights © Nature Publishing Group. http://www.nature.com/tp/journal/v6/n1/full/tp2015214a.html/nThis work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material.ca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/ca
- dc.subject.other ADNca
- dc.subject.other Sistema nerviós Degeneracióca
- dc.title Human DNA methylomes of neurodegenerative diseases show common epigenomic patternsca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/publishedVersionca