Accelerated tumor invasion under non-isotropic cell dispersal in glioblastomas
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- dc.contributor.author Fort, Joaquimca
- dc.contributor.author Solé Vicente, Ricard, 1962-ca
- dc.date.accessioned 2015-06-18T07:03:19Z
- dc.date.available 2015-06-18T07:03:19Z
- dc.date.issued 2013ca
- dc.description.abstract Glioblastomas are highly diffuse, malignant tumors that have so far evaded clinical treatment. The strongly invasive behavior of cells in these tumors makes them very resistant to treatment, and for this reason both experimental and theoretical efforts have been directed toward understanding the spatiotemporal pattern of tumor spreading. Although usual models assume a standard diffusion behavior, recent experiments with cell cultures indicate that cells tend to move in directions close to that of glioblastoma invasion, thus indicating that a biased random walk model may be much more appropriate. Here we show analytically that, for realistic parameter values, the speeds predicted by biased dispersal are consistent with experimentally measured data. We also find that models beyond reaction–diffusion–advection equations are necessary to capture this substantial effect of biased dispersal on glioblastoma spread.en
- dc.description.sponsorship This work was supported by MEC (FIS-2012-31307 grant, JF), the Generalitat de Catalunya (2009-SGR-374 grant, JF), the Marcelino Botín Foundation (RVS) and the Santa Fe Institute (RVS)en
- dc.format.mimetype application/pdfca
- dc.identifier.citation Fort J, Solé Vicente R. Accelerated tumor invasion under non-isotropic cell dispersal in glioblastomas. New Journal of Physics. 2013;15:055001. DOI: 10.1088/1367-2630/15/5/055001ca
- dc.identifier.doi http://dx.doi.org/10.1088/1367-2630/15/5/055001
- dc.identifier.issn 1367-2630ca
- dc.identifier.uri http://hdl.handle.net/10230/23850
- dc.language.iso engca
- dc.publisher IOP Scienceca
- dc.relation.ispartof New Journal of Physics. 2013;15:055001
- dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/FIS2012-31307
- dc.rights Content from this work may be used under the terms of the/nCreative Commons Attribution 3.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI.en
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.rights.uri https://creativecommons.org/licenses/by/3.0/
- dc.subject.other Tumors -- Tractamentca
- dc.subject.other Càncer -- Tractamentca
- dc.title Accelerated tumor invasion under non-isotropic cell dispersal in glioblastomasen
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/publishedVersionca