Climbing fiber regulation of spontaneous purkinje cell activity and cerebellum-dependent blink responses
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- dc.contributor.author Zucca, Riccardo
- dc.contributor.author Rasmussen, Anders
- dc.contributor.author Bengtsson, Fredrik
- dc.date.accessioned 2025-02-03T07:50:01Z
- dc.date.available 2025-02-03T07:50:01Z
- dc.date.issued 2016
- dc.description.abstract It has been known for a long time that GABAergic Purkinje cells in the cerebellar cortex, as well as their target neurons in the cerebellar nuclei, are spontaneously active. The cerebellar output will, therefore, depend on how input is integrated into this spontaneous activity. It has been shown that input from climbing fibers originating in the inferior olive controls the spontaneous activity in Purkinje cells. While blocking climbing fiber input to the Purkinje cells causes a dramatic increase in the firing rate, increased climbing fiber activity results in reduced Purkinje cell activity. However, the exact calibration of this regulation has not been examined systematically. Here we examine the relation between climbing fiber stimulation frequency and Purkinje cell activity in unanesthetized decerebrated ferrets. The results revealed a gradual suppression of Purkinje cell activity, starting at climbing fiber stimulation frequencies as low as 0.5 Hz. At 4 Hz, Purkinje cells were completely silenced. This effect lasted an average of 2 min after the stimulation rate was reduced to a lower level. We also examined the effect of sustained climbing fiber stimulation on overt behavior. Specifically, we analyzed conditioned blink responses, which are known to be dependent on the cerebellum, while stimulating the climbing fibers at different frequencies. In accordance with the neurophysiological data, the conditioned blink responses were suppressed at stimulation frequencies of ≥4 Hz.en
- dc.format.mimetype application/pdf
- dc.identifier.citation Zucca R, Rasmussen A, Bengtsson F. Climbing fiber regulation of spontaneous purkinje cell activity and cerebellum-dependent blink responses. eNeuro. 2016 Jan;3(1):e0067-15.2015. DOI: 10.1523/ENEURO.0067-15.2015
- dc.identifier.doi http://dx.doi.org/10.1523/ENEURO.0067-15.2015
- dc.identifier.issn 2373-2822
- dc.identifier.uri http://hdl.handle.net/10230/69445
- dc.language.iso eng
- dc.publisher Society for Neuroscience
- dc.relation.ispartof eNeuro. 2016 Jan;3(1):e0067-15.2015
- dc.rights © The Authors. Published by the Society for Neuroscience [Must link to publisher version]. The work is published under a Creative Commons Attribution 4.0 International (CC BY 4.0) license, as described at https://creativecommons.org/licenses/by/4.0/
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Climbing fibersen
- dc.subject.keyword Eyeblink conditioningen
- dc.subject.keyword Purkinje cellen
- dc.subject.keyword Simple spikesen
- dc.subject.keyword Spontaneous background firingen
- dc.title Climbing fiber regulation of spontaneous purkinje cell activity and cerebellum-dependent blink responsesen
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion