The abundance of the long intergenic non-coding RNA 01087 differentiates between luminal and triple-negative breast cancers and predicts patient outcome

Palma, Fatima Domenica Elisa de; Monaco, Valentina del; Pol, Jonathan G.; Kremer, Margerie; D'Argenio, Valeria; Stoll, Gautier; Montanaro, Donatella; Uszczynska-Ratajczak, Barbara; Klein, Cecilia C.; Vlasova, Anna; Botti, Gerardo; D'Aiuto, Massimiliano; Baldi, Alfonso; Guigó Serra, Roderic; Kroemer, Guido; Maiuri, Maria Chiara; Salvatore, Francesco

The abundance of the long intergenic non-coding RNA 01087 differentiates between luminal and triple-negative breast cancers and predicts patient outcome

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dc.contributor.author Palma, Fatima Domenica Elisa de
dc.contributor.author Monaco, Valentina del
dc.contributor.author Pol, Jonathan G.
dc.contributor.author Kremer, Margerie
dc.contributor.author D'Argenio, Valeria
dc.contributor.author Stoll, Gautier
dc.contributor.author Montanaro, Donatella
dc.contributor.author Uszczynska-Ratajczak, Barbara
dc.contributor.author Klein, Cecilia C.
dc.contributor.author Vlasova, Anna
dc.contributor.author Botti, Gerardo
dc.contributor.author D'Aiuto, Massimiliano
dc.contributor.author Baldi, Alfonso
dc.contributor.author Guigó Serra, Roderic
dc.contributor.author Kroemer, Guido
dc.contributor.author Maiuri, Maria Chiara
dc.contributor.author Salvatore, Francesco
dc.date.accessioned 2020-11-24T07:07:08Z
dc.date.available 2020-11-24T07:07:08Z
dc.date.issued 2020
dc.description.abstract The molecular complexity of human breast cancer (BC) renders the clinical management of the disease challenging. Long non-coding RNAs (lncRNAs) are promising biomarkers for BC patient stratification, early detection, and disease monitoring. Here, we identified the involvement of the long intergenic non-coding RNA 01087 (LINC01087) in breast oncogenesis. LINC01087 appeared significantly downregulated in triple-negative BCs (TNBCs) and upregulated in the luminal BC subtypes in comparison to mammary samples from cancer-free women and matched normal cancer pairs. Interestingly, deregulation of LINC01087 allowed to accurately distinguish between luminal and TNBC specimens, independently of the clinicopathological parameters, and of the histological and TP53 or BRCA1/2 mutational status. Moreover, increased expression of LINC01087 predicted a better prognosis in luminal BCs, while TNBC tumors that harbored lower levels of LINC01087 were associated with reduced relapse-free survival. Furthermore, bioinformatics analyses were performed on TNBC and luminal BC samples and suggested that the putative tumor suppressor activity of LINC01087 may rely on interferences with pathways involved in cell survival, proliferation, adhesion, invasion, inflammation and drug sensitivity. Altogether, these data suggest that the assessment of LINC01087 deregulation could represent a novel, specific and promising biomarker not only for the diagnosis and prognosis of luminal BC subtypes and TNBCs, but also as a predictive biomarker of pharmacological interventions.
dc.format.mimetype application/pdf
dc.identifier.citation De Palma FDE, Del Monaco V, Pol JG, Kremer M, D'Argenio V, Stoll G, Montanaro D, Uszczynska-Ratajczak B, Klein CC, Vlasova A, Botti G, D'Aiuto M, Baldi A, Guigó R, Kroemer G, Maiuri MC, Salvatore F. The abundance of the long intergenic non-coding RNA 01087 differentiates between luminal and triple-negative breast cancers and predicts patient outcome. Pharmacol Res. 2020 Nov;161:105249. DOI: 10.1016/j.phrs.2020.105249
dc.identifier.doi http://dx.doi.org/10.1016/j.phrs.2020.105249
dc.identifier.issn 1043-6618
dc.identifier.uri http://hdl.handle.net/10230/45878
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Pharmacol Res. 2020 Nov;161:105249
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.keyword Biomarker
dc.subject.keyword Breast cancer
dc.subject.keyword LINC01087
dc.subject.keyword Long non-coding RNA
dc.subject.keyword Luminal breast cancer
dc.subject.keyword Triple-negative breast cancer
dc.title The abundance of the long intergenic non-coding RNA 01087 differentiates between luminal and triple-negative breast cancers and predicts patient outcome
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/publishedVersion

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