The interaction between circulating cell-free mitochondrial DNA and inflammatory cytokines in predicting human mental health issue risk in adolescents: an explorative study
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- dc.contributor.author Alatalo, Arto
- dc.contributor.author Sousa Maciel, Izaque de
- dc.contributor.author Kucháriková, Nina
- dc.contributor.author Chew, Sweelin
- dc.contributor.author Kamp, Irene van
- dc.contributor.author Foraster Pulido, Maria, 1984-
- dc.contributor.author Júlvez Calvo, Jordi
- dc.contributor.author Kanninen, Katja M.
- dc.date.accessioned 2023-06-28T06:40:12Z
- dc.date.available 2023-06-28T06:40:12Z
- dc.date.issued 2023
- dc.description.abstract Adolescence is often a challenging time in which psychiatric issues have a strong connection to mental health disorders later in life. The early identification of the problems can reduce the burden of disease. To date, the effective identification of adolescents at risk of developing mental health problems remains understudied. Altogether, the interaction between circulating cell-free mtDNA (ccf-mtDNA) and inflammatory cytokines in adolescents is insufficiently understood regarding experienced mental health difficulties. Our study selected the participants based on the Strength and Difficulty Questionnaire (SDQ) score using the cut-off points of 3 and 18 for the low and the high score groups, respectively. The answers of the SDQ at the age of 12.2-15.7 years contributed to the investigation of (i) whether ccf-mtDNA units are associated with cytokines, and (ii) if an interaction model for predicting risk of mental health issues is observed. We discovered a sex-specific correlation between the screened markers associated with mental health problems in the low and high SDQ score groups among the male participants and in the low SDQ score group among the female participants. The mitochondrial MT-ND4 and MT-CO1 genes correlated significantly with interleukin-12p70 (IL-12p70) in males and with monocyte chemoattractant protein-1 (MCP-1) in females. Due to the nature of the explorative study, the studied markers alone did not indicate statistical significance for the prediction of mental health problems. Our analysis provided new insight into potential plasma-based biomarkers to predict mental health issues.
- dc.description.sponsorship This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No 874724.
- dc.format.mimetype application/pdf
- dc.identifier.citation Alatalo A, Sousa Maciel I de, Kucháriková N, Chew S, Kamp I van, Foraster M, Julvez J, Kanninen KM. The interaction between circulating cell-free mitochondrial DNA and inflammatory cytokines in predicting human mental health issue risk in adolescents: an explorative study. Biomedicines. 2023;11(3):818. DOI: 10.3390/biomedicines11030818
- dc.identifier.doi http://dx.doi.org/10.3390/biomedicines11030818
- dc.identifier.issn 2227-9059
- dc.identifier.uri http://hdl.handle.net/10230/57383
- dc.language.iso eng
- dc.publisher MDPI
- dc.relation.ispartof Biomedicines. 2023;11(3):818
- dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/874724
- dc.rights © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Adolescence
- dc.subject.keyword Biomarkers
- dc.subject.keyword Inflammation
- dc.subject.keyword Mental health
- dc.subject.keyword Mitochondrial DNA
- dc.subject.keyword Oxidative stress
- dc.title The interaction between circulating cell-free mitochondrial DNA and inflammatory cytokines in predicting human mental health issue risk in adolescents: an explorative study
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion