Gene expression study and pathway analysis of histological subtypes of intestinal metaplasia that progress to gastric cancer

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• dc.contributor.author Companioni, Osmelca
• dc.contributor.author Sanz-Anquela, José Miguelca
• dc.contributor.author Pardo, María Luisaca
• dc.contributor.author Puigdecanet Riubugent, Eulàliaca
• dc.contributor.author Nonell Mazelon, Lara, 1972-ca
• dc.contributor.author García, Nadiaca
• dc.contributor.author Parra Blanco, Verónicaca
• dc.contributor.author López, Consueloca
• dc.contributor.author Andreu, Victoriaca
• dc.contributor.author Cuatrecasas, Miriamca
• dc.contributor.author Garmendia, Maddica
• dc.contributor.author Gisbert, Javier P.ca
• dc.contributor.author González Svatetz, Carlos Albertoca
• dc.contributor.author Sala, Núriaca
• dc.date.accessioned 2018-07-16T08:18:03Z
• dc.date.available 2018-07-16T08:18:03Z
• dc.date.issued 2017
• dc.description.abstract BACKGROUND: Intestinal metaplasia (IM) is a precursor lesion that precedes gastric cancer (GC). There are two IM histological subtypes, complete (CIM) and incomplete (IIM), the latter having higher progression rates to GC. This study was aimed at analysing gene expression and molecular processes involved in the progression from normal mucosa to IM, and also from IM subtypes to GC. METHODOLOGY: We used expression data to compare the transcriptome of healthy gastric mucosa to that of IM not progressing to GC, and the transcriptome of IM subtypes that had progressed to GC to those that did not progress. Some deregulated genes were validated and pathway analyses were performed. RESULTS: Comparison of IM subtypes that had progressed to GC with those that did not progress showed smaller differences in the expression profiles than the comparison of IM that did not progress with healthy mucosa. New transcripts identified in IM not progressing to GC included TRIM, TMEM, homeobox and transporter genes and SNORD116. Comparison to normal mucosa identified non tumoral Warburg effect and melatonin degradation as previously unreported processes involved in IM. Overexpressed antigen processing is common to both IM-subtypes progressing to GC, but IIM showed more over-expressed oncogenic genes and molecular processes than CIM. CONCLUSIONS: There are greater differences in gene expression and molecular processes involved in the progression from normal healthy mucosa to IM than from IM to gastric cancer. While antigen processing is common in both IM-subtypes progressing to GC, more oncogenic processes are observed in the progression of IIM.
• dc.format.mimetype application/pdf
• dc.identifier.citation Companioni O, Sanz-Anquela JM, Pardo ML, Puigdecanet E, Nonell L, García N. et al. Gene expression study and pathway analysis of histological subtypes of intestinal metaplasia that progress to gastric cancer. PLoS One. 2017 Apr 25;12(4):e0176043. DOI: 10.1371/journal.pone.0176043
• dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0176043
• dc.identifier.issn 1932-6203
• dc.identifier.uri http://hdl.handle.net/10230/35165
• dc.language.iso eng
• dc.publisher Public Library of Science (PLoS)ca
• dc.relation.ispartof PLoS One. 2017 Apr 25;12(4):e0176043
• dc.rights Copyright © 2017 Companioni et al. This is an open access article distributed under the terms of the https://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri https://creativecommons.org/licenses/by/4.0/
• dc.subject.other Estómac -- Càncer -- Aspectes genètics
• dc.title Gene expression study and pathway analysis of histological subtypes of intestinal metaplasia that progress to gastric cancerca
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion