Increased stability and breakdown of brain effective connectivity during slow-wave sleep: mechanistic insights from whole-brain computational modelling

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  • dc.contributor.author Jobst, Beatrice M.
  • dc.contributor.author Hindriks, Rikkert
  • dc.contributor.author Laufs, Helmut
  • dc.contributor.author Tagliazucchi, Enzo
  • dc.contributor.author Hahn, Gerald
  • dc.contributor.author Ponce-Alvarez, Adrián
  • dc.contributor.author Stevner, Angus B. A.
  • dc.contributor.author Kringelbach, Morten L.
  • dc.contributor.author Deco, Gustavo
  • dc.date.accessioned 2019-04-11T10:03:42Z
  • dc.date.available 2019-04-11T10:03:42Z
  • dc.date.issued 2017
  • dc.description.abstract Recent research has found that the human sleep cycle is characterised by changes in spatiotemporal patterns of brain activity. Yet, we are still missing a mechanistic explanation of the local neuronal dynamics underlying these changes. We used whole-brain computational modelling to study the differences in global brain functional connectivity and synchrony of fMRI activity in healthy humans during wakefulness and slow-wave sleep. We applied a whole-brain model based on the normal form of a supercritical Hopf bifurcation and studied the dynamical changes when adapting the bifurcation parameter for all brain nodes to best match wakefulness and slow-wave sleep. Furthermore, we analysed differences in effective connectivity between the two states. In addition to significant changes in functional connectivity, synchrony and metastability, this analysis revealed a significant shift of the global dynamic working point of brain dynamics, from the edge of the transition between damped to sustained oscillations during wakefulness, to a stable focus during slow-wave sleep. Moreover, we identified a significant global decrease in effective interactions during slow-wave sleep. These results suggest a mechanism for the empirical functional changes observed during slow-wave sleep, namely a global shift of the brain’s dynamic working point leading to increased stability and decreased effective connectivity.
  • dc.description.sponsorship BMJ, RH, GH, APA and GD were funded by the European Research Council (ERC) Advanced Grant DYSTRUCTURE (n. 295129), European Union’s Horizon 2020 research and innovation programme under grant agreement No. 720270 (HBP SGA1) and No. 661583 (CONSBRAIN), by the Programa Estatal de Investigación Cientifica y Tecnica de Excelencia MINECO (PSI2013-42091, PSI2016-75688-P (AEI/FEDER, EU) and PCIN-2013-026), Juan de la Cierva fellowship (IJCI-2014-21066) and by the Catalan Agency for Management of University and Research Grants, AGAUR (2014SGR856). ET and HL were supported by the Bundesministerium für Bildung und Forschung (grantnumber 01 EV 0703) and the LOEWE Neuronale Koordination Forschungsschwerpunkt Frankfurt (NeFF). ET was further funded by a postdoctoral grant of the AXA foundation. MLK was supported by the ERC Consolidator Grant CAREGIVING (n. 615539).
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Jobst BM, Hindriks R, Laufs H, Tagliazucchi E, Hahn G, Ponce-Alvarez A, Stevner ABA, Kringelbach ML, Deco G. Increased stability and breakdown of brain effective connectivity during slow-wave sleep: mechanistic insights from whole-brain computational modelling. Sci Rep. 2017 Jul 5;7:4634. DOI: 10.1038/s41598-017-04522-x
  • dc.identifier.doi http://dx.doi.org/10.1038/s41598-017-04522-x
  • dc.identifier.issn 2045-2322
  • dc.identifier.uri http://hdl.handle.net/10230/37093
  • dc.language.iso eng
  • dc.publisher Nature Research
  • dc.relation.ispartof Scientific Reports. 2017 Jul 5;7:4634
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/295129
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/720270
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/661583
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/PSI2013-42091
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/PSI2016-75688-P
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/PCIN-2013-026
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/IJCI-2014-21066
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/615539
  • dc.rights © This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.keyword Computational neuroscience
  • dc.subject.keyword Computational science
  • dc.title Increased stability and breakdown of brain effective connectivity during slow-wave sleep: mechanistic insights from whole-brain computational modelling
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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