Unveiling the evolutionary history of european vipers and their venoms from a multi-omic approach

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• dc.contributor.author Talavera, Adrián
• dc.contributor.author Palmada Flores, Marc
• dc.contributor.author Martínez-Freiría, Fernando
• dc.contributor.author Mochales Riaño, Gabriel
• dc.contributor.author Burriel Carranza, Bernat
• dc.contributor.author Estarellas, Maria
• dc.contributor.author Fernández Guiberteau, Daniel
• dc.contributor.author Camina, Álvaro
• dc.contributor.author Ursenbacher, Sylvain
• dc.contributor.author Vörös, Judit
• dc.contributor.author Halpern, Bálint
• dc.contributor.author Pla, Davinia
• dc.contributor.author Calvete, Juan José
• dc.contributor.author Mikheyev, Alexander S.
• dc.contributor.author Marquès i Bonet, Tomàs, 1975-
• dc.contributor.author Carranza Gil-Dolz del Castellar, Salvador
• dc.date.accessioned 2025-09-15T06:20:13Z
• dc.date.available 2025-09-15T06:20:13Z
• dc.date.issued 2025
• dc.description Data de publicació electrònica: 12-07-2025
• dc.description.abstract Snake genomes attract significant attention from multiple disciplines, including medicine, drug bioprospection, and evolutionary biology. However, genomic research within the Viperidae family has mostly focused on the subfamily Crotalinae, while the true vipers (Viperinae) have largely been overlooked. European vipers (Vipera) have been the subject of extensive research due to their phylogeographic and ecological diversification, as well as their venoms. Nevertheless, phylogeography and systematics in this genus have primarily relied on biased information from mitochondrial genes, which fail to capture the likely effects of introgression and are prone to biases. On the other hand, venom research in this group has been conducted predominantly through proteomics alone. In this study, we generated chromosome-level genome assemblies for three Vipera species and whole-genome sequencing data for 94 samples representing 15 Vipera lineages. This comprehensive dataset allowed us to disentangle the phylogenomic relationships of this genus, affected by mito-nuclear discordance and pervaded by ancestral introgression. Population-level analyses in the Iberian Peninsula, where the three oldest lineages within Vipera meet, revealed signals of recent adaptive introgression between old-diverged and ecologically dissimilar species, whereas chromosomal rearrangements isolate species occupying similar niches. Finally, using transcriptomic and proteomic data, we characterised the Vipera toxin-encoding genes, in which opposing selective forces were unveiled as common drivers of the evolution of venom as an integrated phenotype.
• dc.format.mimetype application/pdf
• dc.identifier.citation Talavera A, Palmada-Flores M, Martínez-Freiría F, Mochales-Riaño G, Burriel-Carranza B, Estarellas M, et al. Unveiling the evolutionary history of european vipers and their venoms from a multi-omic approach. Mol Ecol. 2025 Jul 12:e70019. DOI: 10.1111/mec.70019
• dc.identifier.doi http://dx.doi.org/10.1111/mec.70019
• dc.identifier.issn 0962-1083
• dc.identifier.uri http://hdl.handle.net/10230/71195
• dc.language.iso eng
• dc.publisher Wiley
• dc.relation.ispartof Mol Ecol. 2025 Jul 12:e70019
• dc.rights © 2025 The Author(s). Molecular Ecology published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
• dc.subject.keyword Vipera
• dc.subject.keyword Adaptive introgression
• dc.subject.keyword Chromosomal rearrangements
• dc.subject.keyword Genomics
• dc.subject.keyword Mito‐nuclear discordance
• dc.subject.keyword Snakes
• dc.subject.keyword Venom evolution
• dc.title Unveiling the evolutionary history of european vipers and their venoms from a multi-omic approach
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion