Variability of urinary concentrations of non-persistent chemicals in pregnant women and school-aged children

Casas Sanahuja, Maribel; Basagaña Flores, Xavier; Manzano Salgado, Cyntia Beatriz, 1987-; De Bont, Jeroen, 1989-; Donaire González, David; González, Juan Ramón; Gracia Lavedan, Esther; Pañella, Pau; Robinson, Oliver; Urquiza, José M.; Vrijheid, Martine

Variability of urinary concentrations of non-persistent chemicals in pregnant women and school-aged children

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dc.contributor.author Casas Sanahuja, Maribel
dc.contributor.author Basagaña Flores, Xavier
dc.contributor.author Manzano Salgado, Cyntia Beatriz, 1987-
dc.contributor.author De Bont, Jeroen, 1989-
dc.contributor.author Donaire González, David
dc.contributor.author González, Juan Ramón
dc.contributor.author Gracia Lavedan, Esther
dc.contributor.author Pañella, Pau
dc.contributor.author Robinson, Oliver
dc.contributor.author Urquiza, José M.
dc.contributor.author Vrijheid, Martine
dc.date.accessioned 2019-07-26T07:34:35Z
dc.date.available 2019-07-26T07:34:35Z
dc.date.issued 2018
dc.description.abstract Background: Exposome studies are challenged by exposure misclassification for non-persistent chemicals, whose temporal variability contributes to bias in dose-response functions. Objectives: We evaluated the variability of urinary concentrations of 24 non-persistent chemicals: 10 phthalate metabolites, 7 phenols, 6 organophosphate (OP) pesticide metabolites, and cotinine, between weeks from different pregnancy trimesters in pregnant women, and between days and between seasons in children. Methods: 154 pregnant women and 152 children from six European countries were enrolled in 2014–2015. Pregnant women provided three urine samples over a day (morning, midday, and night), for one week in the 2nd and 3rd pregnancy trimesters. Children provided two urines a day (morning and night), over two one-week periods, six months apart. We pooled all samples for a given subject that were collected within a week. In children, we also made four daily pools (combining morning and night voids) during the last four days of the first follow-up week. Pools were analyzed for all 24 metabolites of interest. We calculated intraclass-correlation coefficients (ICC) and estimated the number of pools needed to obtain an ICC above 0.80. Results: All phthalate metabolites and phenols were detected in >90% of pools whereas certain OP pesticide metabolites and cotinine were detected in <43% of pools. We observed fair (ICC = 0.40–0.59) to good (0.60–0.74) between-day reliability of the pools of two samples in children for all chemicals. Reliability was poor (<0.40) to fair between trimesters in pregnant women and between seasons in children. For most chemicals, three daily pools of two urines each (for weekly exposure windows) and four weekly pools of 15–20 urines each would be necessary to obtain an ICC above 0.80. Conclusions: This quantification of the variability of biomarker measurements of many non-persistent chemicals during several time windows shows that for many of these compounds a few dozen samples are required to accurately assess exposure over periods encompassing several trimesters or months.
dc.description.sponsorship The research leading to these results has received funding from the European Community's Seventh Framework Programme (FP7/2007-2013) under grant agreement no 308333 – the HELIX project. Dr. Maribel Casas received funding from Instituto de Salud Carlos III (Ministry of Economy and Competitiveness) (MS16/00128). Dr. Regina Grazuleviciene received the grant of the Lithuanian Agency for Science Innovation and Technology (No. 31V-66). Dr. Juan R Gonzalez is supported by Ministerio de Economía y Competitividad y Fondo Europeo de Desarrollo (MTM2015-68140-R). The pregnant women recruited in Grenoble are part of SEPAGES mother-child cohort, which has been partly funded by a grant from the European Research Council (ERC, consolidator grant #311765-EDOHaD, PI, R. Slama).
dc.format.mimetype application/pdf
dc.identifier.citation Casas M, Basagaña X, Sakhi AK, Haug LS, Philippat C, Granum B et al. Variability of urinary concentrations of non-persistent chemicals in pregnant women and school-aged children. Environ Int. 2018;121(Pt 1):561-73. DOI: 10.1016/j.envint.2018.09.046
dc.identifier.doi http://dx.doi.org/10.1016/j.envint.2018.09.046
dc.identifier.issn 0160-4120
dc.identifier.uri http://hdl.handle.net/10230/42187
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Environment International. 2018;121(Pt 1):561-73
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/308333
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/311765
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/MTM2015-68140-R
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.rights.uri http://creativecommons.org/licenses/BY-NC-ND/4.0/
dc.subject.keyword Phthalate metabolites
dc.subject.keyword Phenols
dc.subject.keyword Organophosphate pesticide metabolites
dc.subject.keyword Pregnancy
dc.subject.keyword Childhood
dc.subject.keyword Intraclass-correlation coefficient
dc.title Variability of urinary concentrations of non-persistent chemicals in pregnant women and school-aged children
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/publishedVersion

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