Identifying COPD patients with poor health status and low exercise tolerance through the five-repetition sit-to-stand test and modified Medical Research Council Dyspnea Score

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• dc.contributor.author Bernabeu Mora, Roberto
• dc.contributor.author Oliveira-Sousa, Silvana Loana
• dc.contributor.author Medina-Mirapeix, Francesc
• dc.contributor.author Gacto-Sánchez, Mariano
• dc.contributor.author Group of Investigation SAQ_COPD
• dc.date.accessioned 2025-05-16T05:43:30Z
• dc.date.available 2025-05-16T05:43:30Z
• dc.date.issued 2024
• dc.description.abstract Background: The objective of this study was to determine whether the concomitant presence of poor health status (COPD Assessment Test, CAT ≥ 10 points) and low exercise tolerance (6-Minute Walking Test, 6MWT < 350 m) is associated with worse clinical characteristics in patients with COPD. In addition, we aimed to develop a readily applicable diagnostic model to discriminate COPD patients with these conditions. Methods: A cross-sectional multicenter study involving 208 stable COPD patients (FEV1/FVC < 0.7, smoking history of at least 10 pack-years, and chronic respiratory symptoms) was carried out. The outcome measures were the 6MWT, CAT score, 5-repetition sit-to-stand test (5STS) and modified Medical Research Council Dyspnea Scale (mMRC). Patients were categorized into three groups: no condition (6MWT ≥ 350 m and CAT < 10 points), one condition (6MWT < 350 m or CAT ≥ 10 points), and both conditions (6MWT < 350 m and CAT ≥ 10 points). Results: A total of 26 patients (12,5%) presented both conditions. These patients experienced a higher degree of dyspnea (p = 0.001), smoking pack-years (p = 0.011), severe obstruction (p = 0.006), and time on 5STS (p = 0.001). The probability of having both conditions directly increased with the time spent on the 5STS (β=0.188; p = 0.010) and the degree of dyspnea (β=1.920; p < 0.001) (R2=0.413). The scoring system, using the 5STS and dyspnea as surrogate measures, demonstrated adequate calibration between the predicted and observed risk (linear R2=0.852). Conclusions: COPD patients with concurrent conditions have worse clinical status. The diagnostic model developed to discriminate these patients shows good internal validation.
• dc.format.mimetype application/pdf
• dc.identifier.citation Bernabéu-Mora R, Oliveira-Sousa SL, Medina-Mirapeix F, Gacto-Sánchez M; Group of Investigation SAQ_COPD. Identifying COPD patients with poor health status and low exercise tolerance through the five-repetition sit-to-stand test and modified Medical Research Council Dyspnea Score. Eur J Intern Med. 2024 Jul;125:51-6. DOI: 10.1016/j.ejim.2024.03.032
• dc.identifier.doi http://dx.doi.org/10.1016/j.ejim.2024.03.032
• dc.identifier.issn 0953-6205
• dc.identifier.uri http://hdl.handle.net/10230/70419
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof Eur J Intern Med. 2024 Jul;125:51-6
• dc.rights © 2024 The Authors. Published by Elsevier B.V. on behalf of European Federation of Internal Medicine. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
• dc.subject.keyword Chronic obstructive pulmonary disease
• dc.subject.keyword Dyspnea
• dc.subject.keyword Exercise tolerance
• dc.subject.keyword Health status
• dc.title Identifying COPD patients with poor health status and low exercise tolerance through the five-repetition sit-to-stand test and modified Medical Research Council Dyspnea Score
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion