Cytokeratin Profile of Basal Cell Carcinomas According to the Degree of Sun Exposure and to the Anatomical Localization

Mostra el registre complet Registre parcial de l'ítem

• dc.contributor.author García de la Fuente, M. Reyesca
• dc.contributor.author Santacana, Mariaca
• dc.contributor.author Valls, Joanca
• dc.contributor.author Vilardell, Felipca
• dc.contributor.author Fernández Armenteros, José Manuelca
• dc.contributor.author Pujol Vallverdú, Ramon Mariaca
• dc.contributor.author Gari, Eloica
• dc.contributor.author Casanova, Josep, Manelca
• dc.date.accessioned 2018-04-09T07:30:42Z
• dc.date.available 2018-04-09T07:30:42Z
• dc.date.issued 2018
• dc.description.abstract Basal cell carcinoma (BCC) seems to originate from ultraviolet light-induced mutations involving the bulge or the outer sheath of the hair follicle cells. However, the etiopathogenic mechanisms involved in the development of these tumors in nonphotoexposed and in hairless areas remain unclear. The cytokeratin (CK) profile (including CK5/6, CK7, CK14, CK15, CK17, and CK19) from a series of different BCC subtypes developing in sun-exposed and non-sun-exposed areas, including hairless regions, was evaluated. The authors have observed that CK7 expression in BCC is associated with the anatomical localization of the tumor and its sun-exposition, but not with other factors such as histological subtype. The expression of this CK is higher in BCCs located in non-sun-exposed and nonhairy areas, such as the vulvar semimucosa and the nipple. Because CK7 is a marker of simple glandular epithelia, the authors suggest a glandular origin for BCCs located in hairless and nonphotoexposed areas.
• dc.format.mimetype application/pdf
• dc.identifier.citation García-de-la-Fuente MR, Santacana M, Valls J, Vilardell F, Fernández Armenteros JM, Pujol R, et al. Cytokeratin Profile of Basal Cell Carcinomas According to the Degree of Sun Exposure and to the Anatomical Localization. Am J Dermatopathol. 2018 May;40(5):342-348. DOI: 10.1097/DAD.0000000000001042
• dc.identifier.doi http://dx.doi.org/10.1097/DAD.0000000000001042
• dc.identifier.issn 0193-1091
• dc.identifier.uri http://hdl.handle.net/10230/34320
• dc.language.iso eng
• dc.publisher Wolters Kluwer (LWW)ca
• dc.relation.ispartof American Journal of Dermatopathology. 2018 May;40(5):342-8
• dc.rights © Wolters Kluwer (LWW) This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/
• dc.subject.other Càncer -- Tractament
• dc.subject.other Cèl·lules canceroses
• dc.title Cytokeratin Profile of Basal Cell Carcinomas According to the Degree of Sun Exposure and to the Anatomical Localizationca
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion