Sequencing primate genomes: what have we learned?
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- dc.contributor.author Marquès i Bonet, Tomàs, 1975-ca
- dc.contributor.author Ryder, Oliver A.ca
- dc.contributor.author Eichler, Evan E.ca
- dc.date.accessioned 2013-04-22T09:57:22Z
- dc.date.available 2013-04-22T09:57:22Z
- dc.date.issued 2009ca
- dc.description.abstract We summarize the progress in whole-genome sequencing and analyses of primate genomes. These emerging genome datasets have broadened our understanding of primate genome evolution revealing unexpected and complex patterns of evolutionary change. This includes the characterization of genome structural variation, episodic changes in the repeat landscape, differences in gene expression, new models regarding speciation, and the ephemeral nature of the recombination landscape. The functional characterization of genomic differences important in primate speciation and adaptation remains a significant challenge. Limited access to biological materials, the lack of detailed phenotypic data and the endangered status of many critical primate species have significantly attenuated research into the genetic basis of primate evolution. Next-generation sequencing technologies promise to greatly expand the number of available primate genome sequences; however, such draft genome sequences will likely miss critical genetic differences within complex genomic regions unless dedicated efforts are put forward to understand the full spectrum of genetic variation.
- dc.description.sponsorship This work was supported by a Marie Curie fellowship
- dc.format.mimetype application/pdfca
- dc.identifier.citation Marques-Bonet T, Ryder OA, Eichler EE. Sequencing primate genomes: what have we learned? Annu Rev Genomics Hum Genet. 2009;10:355-86. DOI: 10.1146/annurev.genom.9.081307.164420ca
- dc.identifier.doi http://dx.doi.org/10.1146/annurev.genom.9.081307.164420
- dc.identifier.issn 1527-8204ca
- dc.identifier.uri http://hdl.handle.net/10230/20563
- dc.language.iso engca
- dc.publisher Annual Reviews Incca
- dc.relation.ispartof Human Genetics. 2009;10:355-86
- dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/220278
- dc.rights Posted with permission from the Annual Review of genomics and human genetics, Volume 10 © by Annual Reviews, http://www.annualreviews.orgca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.subject.keyword Genome
- dc.subject.keyword Sequencing
- dc.subject.keyword Variation
- dc.subject.keyword Gene comparison
- dc.subject.keyword Speciation
- dc.subject.keyword Diversity
- dc.subject.other Genomes
- dc.subject.other Primats -- Genètica
- dc.title Sequencing primate genomes: what have we learned?ca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/acceptedVersionca