Genetic influences on hippocampal subfields: an emerging area of neuroscience research
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- dc.contributor.author Vilor Tejedor, Natàlia, 1988-
- dc.contributor.author Evans, Tavia E.
- dc.contributor.author Adams, Hieab H.
- dc.contributor.author González de Echávarri, José Maria
- dc.contributor.author Molinuevo, José Luis
- dc.contributor.author Guigó Serra, Roderic
- dc.contributor.author Gispert López, Juan Domingo
- dc.contributor.author Operto, Grégory
- dc.date.accessioned 2021-11-24T07:40:38Z
- dc.date.available 2021-11-24T07:40:38Z
- dc.date.issued 2021
- dc.description.abstract There is clear evidence that hippocampal subfield volumes have partly distinct genetic determinants associated with specific biological processes. The identification of genetic correlates of hippocampal subfield volumes may help to elucidate the mechanisms of neurologic diseases, as well as aging and neurodegenerative processes. However, despite the emerging interest in this area of research, the current knowledge of the genetic architecture of hippocampal subfields has not yet been consolidated. We aimed to provide a review of the current evidence from genetic studies of hippocampal subfields, highlighting current priorities and upcoming challenges. The limited number of studies investigating the influential genetic effects on hippocampal subfields, a lack of replicated results and longitudinal designs, and modest sample sizes combined with insufficient standardization of protocols are identified as the most pressing challenges in this emerging area of research.
- dc.format.mimetype application/pdf
- dc.identifier.citation Vilor-Tejedor N, Evans TE, Adams HH, González-de-Echávarri JM, Molinuevo JL, Guigo R, Gispert JD, Operto G. Genetic influences on hippocampal subfields: an emerging area of neuroscience research. Neurol Genet. 2021;7(3):e591. DOI: 10.1212/NXG.0000000000000591
- dc.identifier.doi http://dx.doi.org/10.1212/NXG.0000000000000591
- dc.identifier.issn 2376-7839
- dc.identifier.uri http://hdl.handle.net/10230/49046
- dc.language.iso eng
- dc.publisher Wolters Kluwer (LWW)
- dc.relation.ispartof Neurol Genet. 2021;7(3):e591
- dc.rights © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND), which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
- dc.subject.keyword All global neurology
- dc.subject.keyword All Imaging
- dc.subject.keyword All Genetics
- dc.title Genetic influences on hippocampal subfields: an emerging area of neuroscience research
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion