Periodic spatial patterning with a single morphogen

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• dc.contributor.author Wang, Sheng-Yue
• dc.contributor.author García Ojalvo, Jordi
• dc.contributor.author Elowitz, Michael B.
• dc.date.accessioned 2023-01-16T07:34:38Z
• dc.date.available 2023-01-16T07:34:38Z
• dc.date.issued 2022
• dc.description.abstract During multicellular development, periodic spatial patterning systems generate repetitive structures, such as digits, vertebrae, and teeth. Turing patterning provides a foundational paradigm for understanding such systems. The simplest Turing systems are believed to require at least two morphogens to generate periodic patterns. Here, using mathematical modeling, we show that a simpler circuit, including only a single diffusible morphogen, is sufficient to generate long-range, spatially periodic patterns that propagate outward from transient initiating perturbations and remain stable after the perturbation is removed. Furthermore, an additional bistable intracellular feedback or operation on a growing cell lattice can make patterning robust to noise. Together, these results show that a single morphogen can be sufficient for robust spatial pattern formation and should provide a foundation for engineering pattern formation in the emerging field of synthetic developmental biology.
• dc.description.sponsorship This research was supported by the Allen Discovery Center program under award no. UWSC10142, a Paul G. Allen Frontiers Group advised program of the Paul G. Allen Family Foundation. J.G.-O. was supported by the Spanish Ministry of Science and Innovation and FEDER, under project PGC2018-101251-B-I00, by the “Maria de Maeztu” Programme for Units of Excellence in R&D (grant CEX2018-000792-M), and by the Generalitat de Catalunya. We acknowledge insightful feedback from Elowitz lab members.
• dc.format.mimetype application/pdf
• dc.identifier.citation Wang S, Garcia-Ojalvo J, Elowitz MB. Periodic spatial patterning with a single morphogen. Cell Syst. 2022 Dec 21;13(12):1033-47.e7. DOI: 10.1016/j.cels.2022.11.001
• dc.identifier.doi http://dx.doi.org/10.1016/j.cels.2022.11.001
• dc.identifier.issn 2405-4712
• dc.identifier.uri http://hdl.handle.net/10230/55277
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof Cell Syst. 2022 Dec 21;13(12):1033-47.e7
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PGC2018-101251-B-I00
• dc.rights © 2022 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Pattern formation
• dc.subject.keyword Reaction-diffusion
• dc.subject.keyword Single morphogen
• dc.title Periodic spatial patterning with a single morphogen
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion