Pregnancy-associated plasma protein (PAPP)-A2 in physiology and disease

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• dc.contributor.author Barrios, Vicente
• dc.contributor.author Chowen, Julie A.
• dc.contributor.author Martín Rivada, Álvaro
• dc.contributor.author Guerra-Cantera, Santiago
• dc.contributor.author Pozo-Román, Jesús
• dc.contributor.author Yakar, Shoshana
• dc.contributor.author Rosenfeld, Ron G.
• dc.contributor.author Pérez Jurado, Luis Alberto
• dc.contributor.author Suárez, Juan
• dc.contributor.author Argente, Jesús
• dc.date.accessioned 2022-01-18T06:53:35Z
• dc.date.available 2022-01-18T06:53:35Z
• dc.date.issued 2021
• dc.description.abstract The growth hormone (GH)/insulin-like growth factor (IGF) axis plays fundamental roles during development, maturation, and aging. Members of this axis, composed of various ligands, receptors, and binding proteins, are regulated in a tissue- and time-specific manner that requires precise control that is not completely understood. Some of the most recent advances in understanding the implications of this axis in human growth are derived from the identifications of new mutations in the gene encoding the pregnancy-associated plasma protein PAPP-A2 protease that liberates IGFs from their carrier proteins in a selective manner to allow binding to the IGF receptor 1. The identification of three nonrelated families with mutations in the PAPP-A2 gene has shed light on how this protease affects human physiology. This review summarizes our understanding of the implications of PAPP-A2 in growth physiology, obtained from studies in genetically modified animal models and the PAPP-A2 deficient patients known to date.
• dc.description.sponsorship This research was funded by the Spanish Ministry of Science and Innovation with the help of European FEDER funding (FIS PI19/00166 and PI19/00343), Ministerio de Economía y Competitividad (BFU 2017-82565-C2-1-R) and the Network Center for Biomedical Research on Obesity and Nutrition (CIBEROBN) Instituto Carlos III. S.G.-C. was supported by CIBEROBN.
• dc.format.mimetype application/pdf
• dc.identifier.citation Barrios V, Chowen JA, Martín-Rivada Á, Guerra-Cantera S, Pozo J, Yakar S, Rosenfeld RG, Pérez-Jurado LA, Suárez J, Argente J. Pregnancy-associated plasma protein (PAPP)-A2 in physiology and disease. Cells. 2021;10(12):3576. DOI: 10.3390/cells10123576
• dc.identifier.doi http://dx.doi.org/10.3390/cells10123576
• dc.identifier.issn 2073-4409
• dc.identifier.uri http://hdl.handle.net/10230/52248
• dc.language.iso eng
• dc.publisher MDPI
• dc.relation.ispartof Cells. 2021 Dec 18;10(12):3576
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/BFU2017-82565-C2-1-R
• dc.rights © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword IGF1
• dc.subject.keyword IGF2
• dc.subject.keyword IGFBPs
• dc.subject.keyword PAPP-A
• dc.subject.keyword PAPP-A2
• dc.subject.keyword STC1
• dc.subject.keyword STC2
• dc.subject.keyword Growth hormone axis
• dc.title Pregnancy-associated plasma protein (PAPP)-A2 in physiology and disease
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion