An intrinsically disordered proteins community for ELIXIR

Mostra el registre complet Registre parcial de l'ítem

  • dc.contributor.author Davey, Norman E.
  • dc.contributor.author Notredame, Cedric
  • dc.contributor.author Tosatto, Silvio C.E.
  • dc.date.accessioned 2020-03-20T07:46:26Z
  • dc.date.available 2020-03-20T07:46:26Z
  • dc.date.issued 2019
  • dc.description.abstract Intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) are now recognised as major determinants in cellular regulation. This white paper presents a roadmap for future e-infrastructure developments in the field of IDP research within the ELIXIR framework. The goal of these developments is to drive the creation of high-quality tools and resources to support the identification, analysis and functional characterisation of IDPs. The roadmap is the result of a workshop titled "An intrinsically disordered protein user community proposal for ELIXIR" held at the University of Padua. The workshop, and further consultation with the members of the wider IDP community, identified the key priority areas for the roadmap including the development of standards for data annotation, storage and dissemination; integration of IDP data into the ELIXIR Core Data Resources; and the creation of benchmarking criteria for IDP-related software. Here, we discuss these areas of priority, how they can be implemented in cooperation with the ELIXIR platforms, and their connections to existing ELIXIR Communities and international consortia. The article provides a preliminary blueprint for an IDP Community in ELIXIR and is an appeal to identify and involve new stakeholders.
  • dc.description.sponsorship BW was funded by a grant from the BBSRC [BB/P024092/1]. AB, SO and PLM were supported by the National Eye Institute (NEI), National Human Genome Research Institute (NHGRI), National Heart, Lung, and Blood Institute (NHLBI), National Institute of Allergy and Infectious Diseases (NIAID), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institute of General Medical Sciences (NIGMS), and National Institute of Mental Health (NIMH) of the National Institutes of Health under Award Number [U24HG007822] (the content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health), by European Molecular Biology Laboratory (EMBL) and by the Swiss Federal Government through the State Secretariat for Education, Research and Innovation SERI. AG was supported by the European Molecular Biology Laboratory (EMBL) and the Wellcome Trust [104948]. AE was supported by a Vetenskapsrådet grant [2016-03798]. EP was supported by Danmarks Grundforskningsfond [DNRF125] and a Carlsberg Foundation Distinguished Fellowship [CF18-0314]. JLS was supported by the Israel I-CORE Project: Integrated Structural Cell Biology and by Instruct-ERIC. This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement [778247] and COST Action BM1405 NGP-net.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Davey NE, Babu MM, Blackledge M, Bridge A, Capella-Gutierrez S, Dosztanyi Z et al. An intrinsically disordered proteins community for ELIXIR. F1000Res. 2019; 8. pii: ELIXIR-1753. DOI: 10.12688/f1000research.20136.1
  • dc.identifier.doi http://dx.doi.org/10.12688/f1000research.20136.1
  • dc.identifier.issn 2046-1402
  • dc.identifier.uri http://hdl.handle.net/10230/43967
  • dc.language.iso eng
  • dc.publisher F1000Research
  • dc.relation.ispartof F1000Res. 2019; 8. pii: ELIXIR-1753
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/778247
  • dc.rights © 2019 Davey NE et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.keyword ELIXIR
  • dc.subject.keyword Cellular regulation
  • dc.subject.keyword Community standards
  • dc.subject.keyword Databases
  • dc.subject.keyword Intrinsically disordered proteins
  • dc.subject.keyword Protein dynamics
  • dc.subject.keyword Protein function
  • dc.subject.keyword Protein-protein interactions
  • dc.title An intrinsically disordered proteins community for ELIXIR
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

Col·leccions

Articles (Center for Genomic Regulation (CRG))
Articles (Departament de Medicina i Ciències de la Vida)
Documents OpenAIRE (Open Access Infrastructure for Research in Europe)