Toward integrated management of cerebral aneurysms

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• dc.contributor.author Villa-Uriol, Maria-Cruzca
• dc.contributor.author Larrabide, Ignacio, 1978-ca
• dc.contributor.author Pozo Soler, José Ma. (José María)ca
• dc.contributor.author Kim, Minsuokca
• dc.contributor.author Camara, Oscarca
• dc.contributor.author Craene, Mathieu deca
• dc.contributor.author Zhang, Chongca
• dc.contributor.author Geers, Arjanca
• dc.contributor.author Morales, Hernán G.ca
• dc.contributor.author Bogunovic, Hrvojeca
• dc.contributor.author Cardenes, Rubénca
• dc.contributor.author Frangi Caregnato, Alejandroca
• dc.date.accessioned 2012-07-09T09:58:43Z
• dc.date.available 2012-07-09T09:58:43Z
• dc.date.issued 2010ca
• dc.description.abstract In the last few years, some of the visionary concepts behind the virtual physiological human began to be demonstrated on various clinical domains, showing great promise for improving healthcare management. In the current work, we provide an overview of image- and biomechanics-based techniques that, when put together, provide a patient-specific pipeline for the management of intracranial aneurysms. The derivation and subsequent integration of morphological, morphodynamic, haemodynamic and structural analyses allow us to extract patient-specific models and information from which diagnostic and prognostic descriptors can be obtained. Linking such new indices with relevant clinical events should bring new insights into the processes behind aneurysm genesis, growth and rupture. The development of techniques for modelling endovascular devices such as stents and coils allows the evaluation of alternative treatment scenarios before the intervention takes place and could also contribute to the understanding and improved design of more effective devices. A key element to facilitate the clinical take-up of all these developments is their comprehensive validation. Although a number of previously published results have shown the accuracy and robustness of individual components, further efforts should be directed to demonstrate the diagnostic and prognostic efficacy of these advanced tools through large-scale clinical trials.
• dc.description.sponsorship This work was partially supported by the @neurIST Integrated Project (co-financed by the European Commission through contract no. IST-027703), a CDTI CENIT-CDTEAM grant funded by the Spanish Ministry of Science and Innovation (MICINN-CDTI) and Philips Healthcare (Best, The Netherlands). The authors are also grateful for the support provided by ANSYS Inc. (Canonsburg, PA, USA).
• dc.format.mimetype application/pdfca
• dc.identifier.citation Villa-Uriol M C, Larrabide I, Pozo J M, Kim M, Camara O, De Craene M, Zhang C, Geers A J, Morales H, Bogunovic H, Cardenes R, Frangi A F. Toward integrated management of cerebral aneurysms. Philos Transact A Math Phys Eng Sci. 2010; 368(1921): 2961-2982. DOI: 10.1098/rsta.2010.0095ca
• dc.identifier.doi http://dx.doi.org/10.1098/rsta.2010.0095
• dc.identifier.issn 1364-503Xca
• dc.identifier.uri http://hdl.handle.net/10230/16686
• dc.language.iso engca
• dc.publisher Royal Societyca
• dc.relation.ispartof Philos Transact A Math Phys Eng Sci. 2010; 368(1921): 2961-2982
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP6/027703
• dc.rights © 2010, The Royal Society. The definitive published article can be found at http://rsta.royalsocietypublishing.org/content/368/1921/2961ca
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword Cerebral aneurysms
• dc.subject.keyword Image segmentation
• dc.subject.keyword Morphological characterization
• dc.subject.keyword Computational haemodynamics
• dc.subject.keyword Virtual treatment
• dc.subject.keyword Virtual physiological human
• dc.subject.other Diagnòstic per la imatge
• dc.subject.other Aneurismes cerebrals
• dc.title Toward integrated management of cerebral aneurysmsca
• dc.type info:eu-repo/semantics/articleca
• dc.type.version info:eu-repo/semantics/acceptedVersion