Impact of virgin olive oil and phenol-enriched virgin olive oils on the HDL Proteome in hypercholesterolemic subjects: a double blind, randomized, controlled, cross-over clinical trial (VOHF Study).

Pedret, Anna; Catalán, Úrsula; Fernández-Castillejo, Sara; Farràs Mañé, Marta; Valls, Rosa M.; Rubió, Laura; Canela, Núria; Aragonés, Gerard; Romeu, Marta; Castañer, Olga; Torre Fornell, Rafael de la; Covas Planells, Maria Isabel; Fitó Colomer, Montserrat; Motilva, Maria-José; Solà, Rosa

Impact of virgin olive oil and phenol-enriched virgin olive oils on the HDL Proteome in hypercholesterolemic subjects: a double blind, randomized, controlled, cross-over clinical trial (VOHF Study).

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dc.contributor.author Pedret, Annaca
dc.contributor.author Catalán, Úrsulaca
dc.contributor.author Fernández-Castillejo, Saraca
dc.contributor.author Farràs Mañé, Martaca
dc.contributor.author Valls, Rosa M.ca
dc.contributor.author Rubió, Lauraca
dc.contributor.author Canela, Núriaca
dc.contributor.author Aragonés, Gerardca
dc.contributor.author Romeu, Martaca
dc.contributor.author Castañer, Olgaca
dc.contributor.author Torre Fornell, Rafael de laca
dc.contributor.author Covas Planells, Maria Isabelca
dc.contributor.author Fitó Colomer, Montserratca
dc.contributor.author Motilva, Maria-Joséca
dc.contributor.author Solà, Rosaca
dc.date.accessioned 2015-10-01T11:09:06Z
dc.date.available 2015-10-01T11:09:06Z
dc.date.issued 2015
dc.description.abstract The effects of olive oil phenolic compounds (PCs) on HDL proteome, with respect to new aspects of cardioprotective properties, are still unknown. The aim of this study was to assess the impact on the HDL protein cargo of the intake of virgin olive oil (VOO) and two functional VOOs, enriched with their own PCs (FVOO) or complemented with thyme PCs (FVOOT), in hypercholesterolemic subjects. Eligible volunteers were recruited from the IMIM-Hospital del Mar Medical Research Institute (Spain) from April 2012 to September 2012. Thirty-three hypercholesterolemic participants (total cholesterol >200 mg/dL; 19 men and 14 women; aged 35 to 80 years) were randomized in the double-blind, controlled, cross-over VOHF clinical trial. The subjects received for 3 weeks 25 mL/day of: VOO, FVOO, or FVOOT. Using a quantitative proteomics approach, 127 HDL-associated proteins were identified. Among these, 15 were commonly differently expressed after the three VOO interventions compared to baseline, with specific changes observed for each intervention. The 15 common proteins were mainly involved in the following pathways: LXR/RXR activation, acute phase response, and atherosclerosis. The three VOOs were well tolerated by all participants. Consumption of VOO, or phenol-enriched VOOs, has an impact on the HDL proteome in a cardioprotective mode by up-regulating proteins related to cholesterol homeostasis, protection against oxidation and blood coagulation while down-regulating proteins implicated in acute-phase response, lipid transport, and immune response. The common observed protein expression modifications after the three VOOs indicate a major matrix effect. TRIAL REGISTRATION: International Standard Randomized Controlled Trials ISRCTN77500181.ca
dc.description.sponsorship This study was supported by: the Ministerio de Economia y Competitividad (AGL2012-40144-C03-02; AGL2012-40144-C03-01 and AGL2012-40144-C03-03 projects and, AGL2009-13517-C03-01 and AGL2009-13517-C03-03 project), CIBEROBN,/nFPI fellowship (BES-2010-040766), ISCIII and Departament de Salut joint contract (CP06/00100)./nAP is a post-graduate research student supported by the Universitat Rovira i Virgili and the Centre/nTecnològic de Nutrició i Salut (CTNS).
dc.format.mimetype application/pdfca
dc.identifier.citation Pedret A, Catalán Ú, Fernández-Castillejo S, Farràs M, Valls RM, Rubió L. et al. Impact of virgin olive oil and phenol-enriched virgin olive oils on the HDL Proteome in hypercholesterolemic subjects: a double blind, randomized, controlled, cross-over clinical trial (VOHF Study). PLoS One. 2015 Jun 10;10(6):e0129160. DOI: 10.1371/journal.pone.0129160.ca
dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0129160
dc.identifier.issn 1932-6203
dc.identifier.uri http://hdl.handle.net/10230/24793
dc.language.iso engca
dc.publisher Public Library of Scienceca
dc.relation.ispartof PLoS One. 2015 Jun 10;10(6):e0129160
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/AGL2012-40144
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/AGL2009-13517
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BES2010-040766
dc.rights © 2015 Pedret et al. This is an open access article distributed under the terms of the http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ca
dc.rights.accessRights info:eu-repo/semantics/openAccessca
dc.rights.uri http://creativecommons.org/licenses/by/4.0/ca
dc.subject.other Oli d'oliva -- Aspectes nutricionalsca
dc.subject.other Hipercolesterolèmiaca
dc.title Impact of virgin olive oil and phenol-enriched virgin olive oils on the HDL Proteome in hypercholesterolemic subjects: a double blind, randomized, controlled, cross-over clinical trial (VOHF Study).ca
dc.type info:eu-repo/semantics/articleca
dc.type.version info:eu-repo/semantics/publishedVersionca

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Articles (Hospital del Mar Research Institute)
Articles (Departament de Medicina i Ciències de la Vida)