Functional cure of a chronic virus infection by shifting the virus - host equilibrium state
Mostra el registre complet Registre parcial de l'ítem
- dc.contributor.author Bocharov, Gennady A.
- dc.contributor.author Grebennikov, Dmitry
- dc.contributor.author Cebollada Rica, Paula
- dc.contributor.author Domenjó Vila, Eva, 1993-
- dc.contributor.author Casella, Valentina, 1991-
- dc.contributor.author Meyerhans, Andreas
- dc.date.accessioned 2022-11-14T07:13:29Z
- dc.date.available 2022-11-14T07:13:29Z
- dc.date.issued 2022
- dc.description.abstract The clinical handling of chronic virus infections remains a challenge. Here we describe recent progress in the understanding of virus - host interaction dynamics. Based on the systems biology concept of multi-stability and the prediction of multiplicative cooperativity between virus-specific cytotoxic T cells and neutralising antibodies, we argue for the requirements to engage multiple immune system components for functional cure strategies. Our arguments are derived from LCMV model system studies and are translated to HIV-1 infection.
- dc.description.sponsorship The authors are supported by the Russian Science Foundation (RSF grant no. 18-11-00171), the Russian Foundation of Basic Research (RFBR grant no. 20-01-00352), “la Caixa” Foundation under the project code HR17-00199, the Spanish Ministry of Science and Innovation grant no. PID2019-106323RB-I00 AEI//10.13039/501100011033, and “Unidad de Excelencia María de Maeztu”, funded by the MCIN and the AEI (DOI: 10.13039/501100011033) Ref: CEX2018-000792-M.
- dc.format.mimetype application/pdf
- dc.identifier.citation Bocharov G, Grebennikov D, Cebollada Rica P, Domenjo-Vila E, Casella V, Meyerhans A. Functional cure of a chronic virus infection by shifting the virus - host equilibrium state. Front Immunol. 2022 Aug 30;13:904342. DOI: 10.3389/fimmu.2022.904342
- dc.identifier.doi http://dx.doi.org/10.3389/fimmu.2022.904342
- dc.identifier.issn 1664-3224
- dc.identifier.uri http://hdl.handle.net/10230/54831
- dc.language.iso eng
- dc.publisher Frontiers
- dc.relation.ispartof Front Immunol. 2022 Aug 30;13:904342
- dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2019-106323RB-I00
- dc.rights © 2022 Bocharov, Grebennikov, Cebollada Rica, Domenjo-Vila, Casella and Meyerhans. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Chronic virus infections
- dc.subject.keyword HIV (human immunodeficiency virus)
- dc.subject.keyword LCMV (lymphocytic choriomeningitis virus)
- dc.subject.keyword Cure strategies
- dc.subject.keyword Multi-stability
- dc.subject.keyword Shifting equilibrium states
- dc.title Functional cure of a chronic virus infection by shifting the virus - host equilibrium state
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion