HIV infection is associated with upregulated circulating levels of the inflammaging miR-21-5p

Meseguer Donlo, Javier; Soldado Folgado, Jade; Du, Juan; González Mena, Alicia; Blasco-Hernando, Fabiola; Cañas-Ruano, Esperanza; Nogués Solan, Francesc Xavier; Knobel Freud, Hernando; Garcia Giralt, Natàlia; Güerri Fernández, Roberto

HIV infection is associated with upregulated circulating levels of the inflammaging miR-21-5p

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dc.contributor.author Meseguer Donlo, Javier
dc.contributor.author Soldado Folgado, Jade
dc.contributor.author Du, Juan
dc.contributor.author González Mena, Alicia
dc.contributor.author Blasco-Hernando, Fabiola
dc.contributor.author Cañas-Ruano, Esperanza
dc.contributor.author Nogués Solan, Francesc Xavier
dc.contributor.author Knobel Freud, Hernando
dc.contributor.author Garcia Giralt, Natàlia
dc.contributor.author Güerri Fernández, Roberto
dc.date.accessioned 2024-05-22T07:24:13Z
dc.date.available 2024-05-22T07:24:13Z
dc.date.issued 2023
dc.description.abstract Background: HIV infection produces a chronic inflammation which leads to early aging of people living with HIV. Even though antiretroviral treatments (ART) have significantly increased HIV patient survival, an underlying chronic inflammation persists leading to HIV-related comorbidities. In this context, changes in microRNAs (miRNAs) expression may contribute to this inflammatory response. This study aims to detect differential expression of circulating miRNAs in treatment-naïve HIV-infected individuals compared to uninfected controls and evaluation of altered miRNAs after one year of ART. Methods: Serum from patients and controls was collected at baseline and after 48-weeks on ART in HIV-treated patients. Circulating miRNAs were analysed using next generation sequencing. Results: A total of 32 HIV patients and 10 controls were recruited. Of HIV+ individuals, 7 were long-term non-progressors (elite controllers), a group of HIV-infected individuals that spontaneously control the infection. Higher circulating levels of miR-21-5p, and lower levels of miR-6503-3p and miR-3135b were detected in HIV+ progressors. After one year of ART, these miRNAs remain altered. Moreover, miR-21-5p and miR-6503-3p were also altered in elite controllers compared to control group. In silico analyses showed that miR-21-5p target pathways are related to inflammation mechanisms and immune system. Conclusion: miR-21-5p circulating levels are involved in inflammation and oxidative stress mechanisms in HIV patients even after one year of ART or in elite controllers.
dc.format.mimetype application/pdf
dc.identifier.citation Meseguer-Donlo J, Soldado-Folgado J, Du J, González-Mena A, Blasco-Hernando F, Cañas-Ruano E, et al. HIV infection is associated with upregulated circulating levels of the inflammaging miR-21-5p. J Microbiol Immunol Infect. 2023 Oct;56(5):931-8. DOI: 10.1016/j.jmii.2023.07.011
dc.identifier.doi http://dx.doi.org/10.1016/j.jmii.2023.07.011
dc.identifier.issn 1684-1182
dc.identifier.uri http://hdl.handle.net/10230/60214
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof J Microbiol Immunol Infect. 2023 Oct;56(5):931-8
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.subject.keyword ART
dc.subject.keyword HIV infection
dc.subject.keyword Long-term non-progressors
dc.subject.keyword MicroRNA
dc.subject.keyword NGS
dc.title HIV infection is associated with upregulated circulating levels of the inflammaging miR-21-5p
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/publishedVersion

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Articles (Hospital del Mar Research Institute)
Articles (Departament de Medicina i Ciències de la Vida)