Cross-national comparison of screening mammography accuracy measures in U.S., Norway, and Spain.

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• dc.contributor.author Domingo, Laiaca
• dc.contributor.author Hofvind, Solveigca
• dc.contributor.author Hubbard, Rebecca A.ca
• dc.contributor.author Román, Martaca
• dc.contributor.author Benkese, Davidca
• dc.contributor.author Sala, Mariaca
• dc.contributor.author Castells, Xavierca
• dc.date.accessioned 2016-10-26T08:42:16Z
• dc.date.available 2016-10-26T08:42:16Z
• dc.date.issued 2016
• dc.description.abstract OBJECTIVE: To compare accuracy measures for mammographic screening in Norway, Spain, and the US. METHODS: Information from women aged 50-69 years who underwent mammographic screening 1996-2009 in the US (898,418 women), Norway (527,464), and Spain (517,317) was included. Screen-detected cancer, interval cancer, and the false-positive rates, sensitivity, specificity, positive predictive value (PPV) for recalls (PPV-1), PPV for biopsies (PPV-2), 1/PPV-1 and 1/PPV-2 were computed for each country. Analyses were stratified by age, screening history, time since last screening, calendar year, and mammography modality. RESULTS: The rate of screen-detected cancers was 4.5, 5.5, and 4.0 per 1000 screening exams in the US, Norway, and Spain respectively. The highest sensitivity and lowest specificity were reported in the US (83.1 % and 91.3 %, respectively), followed by Spain (79.0 % and 96.2 %) and Norway (75.5 % and 97.1 %). In Norway, Spain and the US, PPV-1 was 16.4 %, 9.8 %, and 4.9 %, and PPV-2 was 39.4 %, 38.9 %, and 25.9 %, respectively. The number of women needed to recall to detect one cancer was 20.3, 6.1, and 10.2 in the US, Norway, and Spain, respectively. CONCLUSIONS: Differences were found across countries, suggesting that opportunistic screening may translate into higher sensitivity at the cost of lower specificity and PPV. KEY POINTS: • Positive predictive value is higher in population-based screening programmes in Spain and Norway. • Opportunistic mammography screening in the US has lower positive predictive value. • Screening settings in the US translate into higher sensitivity and lower specificity. • The clinical burden may be higher for women screened opportunistically.ca
• dc.description.sponsorship This work was partially supported by grants from Instituto de Salud Carlos III FEDER (PI11/01296), BELE Study, the National Institutes of Health (T32CA09168), and the National Cancer Institute-funded Breast Cancer Surveillance Consortium (HHSN261201100031C). The collection of US cancer and vital status data used in this study was supported in part by several state public health departments and cancer registries
• dc.format.mimetype application/pdfca
• dc.identifier.citation Domingo L, Hofvind S, Hubbard RA, Román M, Benkeser D, Sala M. et al. Cross-national comparison of screening mammography accuracy measures in U.S., Norway, and Spain. Eur Radiol. 2016 Aug;26(8):2520-8. doi: 10.1007/s00330-015-4074-8ca
• dc.identifier.doi http://dx.doi.org/10.1007/s00330-015-4074-8
• dc.identifier.issn 0938-7994
• dc.identifier.uri http://hdl.handle.net/10230/27431
• dc.language.iso engca
• dc.publisher Springerca
• dc.relation.ispartof European Radiology. 2016 Aug;26(8):2520-8
• dc.rights This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.ca
• dc.rights.accessRights info:eu-repo/semantics/openAccessca
• dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/ca
• dc.subject.other Mama -- Radiografiaca
• dc.title Cross-national comparison of screening mammography accuracy measures in U.S., Norway, and Spain.ca
• dc.type info:eu-repo/semantics/articleca
• dc.type.version info:eu-repo/semantics/publishedVersionca