Adipose tissue coregulates cognitive function

Mostra el registre complet Registre parcial de l'ítem

• dc.contributor.author Oliveras Cañellas, Núria
• dc.contributor.author Castells-Nobau, Anna
• dc.contributor.author Vega-Correa, Lisset de la
• dc.contributor.author Latorre-Luque, Jessica
• dc.contributor.author Motger-Albertí, Anna
• dc.contributor.author Arnoriaga Rodríguez, María
• dc.contributor.author Garre-Olmo, Josep
• dc.contributor.author Zapata-Tona, Cristina
• dc.contributor.author Coll Martínez, Clàudia
• dc.contributor.author Ramió-Torrentà, Lluís
• dc.contributor.author Moreno-Navarrete, José Maria
• dc.contributor.author Puig, Josep
• dc.contributor.author Villarroya, Francesc
• dc.contributor.author Ramos, Rafel
• dc.contributor.author Casadó-Anguera, Verònica
• dc.contributor.author Martín García, Elena, 1975-
• dc.contributor.author Maldonado, Rafael, 1961-
• dc.contributor.author Mayneris Perxachs, Jordi
• dc.contributor.author Fernández Real, Jose M.
• dc.date.accessioned 2023-10-09T06:26:43Z
• dc.date.available 2023-10-09T06:26:43Z
• dc.date.issued 2023
• dc.description.abstract Obesity is associated with cognitive decline. Recent observations in mice propose an adipose tissue (AT)-brain axis. We identified 188 genes from RNA sequencing of AT in three cohorts that were associated with performance in different cognitive domains. These genes were mostly involved in synaptic function, phosphatidylinositol metabolism, the complement cascade, anti-inflammatory signaling, and vitamin metabolism. These findings were translated into the plasma metabolome. The circulating blood expression levels of most of these genes were also associated with several cognitive domains in a cohort of 816 participants. Targeted misexpression of candidate gene ortholog in the Drosophila fat body significantly altered flies memory and learning. Among them, down-regulation of the neurotransmitter release cycle-associated gene SLC18A2 improved cognitive abilities in Drosophila and in mice. Up-regulation of RIMS1 in Drosophila fat body enhanced cognitive abilities. Current results show previously unidentified connections between AT transcriptome and brain function in humans, providing unprecedented diagnostic/therapeutic targets in AT.
• dc.format.mimetype application/pdf
• dc.identifier.citation Oliveras-Cañellas N, Castells-Nobau A, de la Vega-Correa L, Latorre-Luque J, Motger-Albertí A, Arnoriaga-Rodriguez M, Garre-Olmo J, Zapata-Tona C, Coll-Martínez C, Ramió-Torrentà L, Moreno-Navarrete JM, Puig J, Villarroya F, Ramos R, Casadó-Anguera V, Martín-García E, Maldonado R, Mayneris-Perxachs J, Fernández-Real JM. Adipose tissue coregulates cognitive function. Sci Adv. 2023 Aug 11;9(32):eadg4017. DOI: 10.1126/sciadv.adg4017
• dc.identifier.doi http://dx.doi.org/10.1126/sciadv.adg4017
• dc.identifier.issn 2375-2548
• dc.identifier.uri http://hdl.handle.net/10230/58058
• dc.language.iso eng
• dc.publisher American Association for the Advancement of Science (AAAS)
• dc.relation.ispartof Sci Adv. 2023 Aug 11;9(32):eadg4017
• dc.rights © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license, which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
• dc.title Adipose tissue coregulates cognitive function
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion