Social inequalities in pregnancy metabolic profile: findings from the multi-ethnic Born in Bradford cohort study

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  • dc.contributor.author Elhakeem, Ahmed
  • dc.contributor.author Clayton, Gemma L.
  • dc.contributor.author Gonçalves Soares, Ana
  • dc.contributor.author Taylor, Kurt
  • dc.contributor.author Maitre, Léa
  • dc.contributor.author Santorelli, Gillian
  • dc.contributor.author Wright, John
  • dc.contributor.author Lawlor, Deborah
  • dc.contributor.author Vrijheid, Martine
  • dc.date.accessioned 2024-07-10T06:20:24Z
  • dc.date.available 2024-07-10T06:20:24Z
  • dc.date.issued 2024
  • dc.description.abstract Background: Lower socioeconomic position (SEP) associates with adverse pregnancy and perinatal outcomes and with less favourable metabolic profile in nonpregnant adults. Socioeconomic differences in pregnancy metabolic profile are unknown. We investigated association between a composite measure of SEP and pregnancy metabolic profile in White European (WE) and South Asian (SA) women. Methods: We included 3,905 WE and 4,404 SA pregnant women from a population-based UK cohort. Latent class analysis was applied to nineteen individual, household, and area-based SEP indicators (collected by questionnaires or linkage to residential address) to derive a composite SEP latent variable. Targeted nuclear magnetic resonance spectroscopy was used to determine 148 metabolic traits from mid-pregnancy serum samples. Associations between SEP and metabolic traits were examined using linear regressions adjusted for gestational age and weighted by latent class probabilities. Results: Five SEP sub-groups were identified and labelled 'Highest SEP' (48% WE and 52% SA), 'High-Medium SEP' (77% and 23%), 'Medium SEP' (56% and 44%) 'Low-Medium SEP' (21% and 79%), and 'Lowest SEP' (52% and 48%). Lower SEP was associated with more adverse levels of 113 metabolic traits, including lower high-density lipoprotein (HDL) and higher triglycerides and very low-density lipoprotein (VLDL) traits. For example, mean standardized difference (95%CI) in concentration of small VLDL particles (vs. Highest SEP) was 0.12 standard deviation (SD) units (0.05 to 0.20) for 'Medium SEP' and 0.25SD (0.18 to 0.32) for 'Lowest SEP'. There was statistical evidence of ethnic differences in associations of SEP with 31 traits, primarily characterised by stronger associations in WE women e.g., mean difference in HDL cholesterol in WE and SA women respectively (vs. Highest-SEP) was -0.30SD (-0.41 to -0.20) and -0.16SD (-0.27 to -0.05) for 'Medium SEP', and -0.62SD (-0.72 to -0.52) and -0.29SD (-0.40 to -0.20) for 'Lowest SEP'. Conclusions: We found widespread socioeconomic differences in metabolic traits in pregnant WE and SA women residing in the UK. Further research is needed to understand whether the socioeconomic differences we observe here reflect pre-conception differences or differences in the metabolic pregnancy response. If replicated, it would be important to explore if these differences contribute to socioeconomic differences in pregnancy outcomes.
  • dc.description.sponsorship This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreements No. 874583 (ATHLETE), and No. 874739 (LongITools) and the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 101021566 (ART-HEALTH), which contribute to part of AE and DAL’s salary. AE, GLC, AGS, KT, and DAL work in a unit supported by the University of Bristol and UK Medical Research Council (MC_UU_00032/05 & MC_UU_00032/02) and DAL’s contribution to this research is further supported by the British Heart Foundation (CH/F/20/90003 & AA/18/1/34219). BiB has received funding from the Wellcome Trust (101597), a joint grant from the UK Medical Research Council and UK Economic and Social Science Research Council (MR/N024391/1), and a British Heart Foundation Clinical Study grant (CS/16/4/32482). ISGlobal acknowledges support from the grant CEX2018-000806-S funded by MCIN/AEI/ https://doi.org/10.13039/501100011033, and support from the Generalitat de Catalunya through the CERCA Program. The funders had no role in the design and conduct of the study; management, analysis, and interpretation of data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Elhakeem A, Clayton GL, Soares AG, Taylor K, Maitre L, Santorelli G, et al. Social inequalities in pregnancy metabolic profile: findings from the multi-ethnic Born in Bradford cohort study. BMC Pregnancy Childbirth. 2024 Apr 30;24(1):333. DOI: 10.1186/s12884-024-06538-4
  • dc.identifier.doi http://dx.doi.org/10.1186/s12884-024-06538-4
  • dc.identifier.issn 1471-2393
  • dc.identifier.uri http://hdl.handle.net/10230/60712
  • dc.language.iso eng
  • dc.publisher BioMed Central
  • dc.relation.ispartof BMC Pregnancy Childbirth. 2024 Apr 30;24(1):333
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/874739
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/874583
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/101021566
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/CEX2018-000806-S
  • dc.rights © The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.keyword Ethnicity
  • dc.subject.keyword Metabolomics
  • dc.subject.keyword Pregnancy
  • dc.subject.keyword Socioeconomic
  • dc.title Social inequalities in pregnancy metabolic profile: findings from the multi-ethnic Born in Bradford cohort study
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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Articles (Barcelona Institute for Global Health (ISGlobal) – Campus Mar)
Articles (Departament de Medicina i Ciències de la Vida)
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