Maternal pre-pregnancy obesity and neuropsychological development in pre-school children: a prospective cohort study
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- dc.contributor.author Casas Sanahuja, Maribelca
- dc.contributor.author Forns i Guzman, Joan, 1981-ca
- dc.contributor.author Martínez Muriano, Davidca
- dc.contributor.author Guxens Junyent, Mònicaca
- dc.contributor.author Fernández-Somoano, Anaca
- dc.contributor.author Ibarluzea, Jesúsca
- dc.contributor.author Lertxundi, Nereaca
- dc.contributor.author Murcia, Marioca
- dc.contributor.author Rebagliato, Marisaca
- dc.contributor.author Tardón, Adoninaca
- dc.contributor.author Sunyer Deu, Jordica
- dc.contributor.author Vrijheid, Martineca
- dc.date.accessioned 2018-06-05T09:08:01Z
- dc.date.available 2018-06-05T09:08:01Z
- dc.date.issued 2017
- dc.description.abstract BackgroundMaternal pre-pregnancy obesity may impair infant neuropsychological development, but it is unclear whether intrauterine or confounding factors drive this association.MethodsWe assessed whether maternal pre-pregnancy obesity was associated with neuropsychological development in 1,827 Spanish children. At 5 years, cognitive and psychomotor development was assessed using McCarthy Scales of Children's Abilities, attention deficit hyperactivity disorder (ADHD) symptoms using the Criteria of Diagnostic and Statistical Manual of Mental Disorders, and autism spectrum disorder symptoms using the Childhood Asperger Syndrome Test. Models were adjusted for sociodemographic factors and maternal intelligence quotient. We used paternal obesity as negative control exposure as it involves the same source of confounding than maternal obesity.ResultsThe percentage of obese mothers and fathers was 8% and 12%, respectively. In unadjusted models, children of obese mothers had lower scores than children of normal weight mothers in all McCarthy subscales. After adjustment, only the verbal subscale remained statistically significantly reduced (β: -2.8; 95% confidence interval: -5.3, -0.2). No associations were observed among obese fathers. Maternal and paternal obesity were associated with an increase in ADHD-related symptoms. Parental obesity was not associated with autism symptoms.ConclusionMaternal pre-pregnancy obesity was associated with a reduction in offspring verbal scores at pre-school age.
- dc.description.sponsorship This study was funded by grants from European Union (FP7-ENV-2011 cod 282957 and HEALTH.2010.2.4.5-1)
- dc.format.mimetype application/pdf
- dc.identifier.citation Casas M, Forns J, Martínez D, Guxens M, Fernandez-Somoano A, Ibarluzea J et al. Maternal pre-pregnancy obesity and neuropsychological development in pre-school children: a prospective cohort study. Pediatr Res. 2017 Oct; 82(4): 596-606. DOI: 10.1038/pr.2017.118
- dc.identifier.doi http://dx.doi.org/10.1038/pr.2017.118
- dc.identifier.issn 0031-3998
- dc.identifier.uri http://hdl.handle.net/10230/34828
- dc.language.iso eng
- dc.publisher Nature Publishing Groupca
- dc.relation.ispartof Pediatric Research. 2017 Oct;82(4):596-606
- dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/282957
- dc.rights © Nature Publishing Group. http://dx.doi.org/10.1038/pr.2017.118
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.subject.other Embaràs
- dc.subject.other Neuropsicologia pediàtrica
- dc.subject.other Ensenyament preescolar
- dc.title Maternal pre-pregnancy obesity and neuropsychological development in pre-school children: a prospective cohort studyca
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/acceptedVersion