MITEA: a dataset for machine learning segmentation of the left ventricle in 3D echocardiography using subject-specific labels from cardiac magnetic resonance imaging

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• dc.contributor.author Zhao, Debbie
• dc.contributor.author Ferdian, Edward
• dc.contributor.author Maso Talou, Gonzalo Daniel
• dc.contributor.author Quill, Gina M.
• dc.contributor.author Gilbert, Kathleen
• dc.contributor.author Wang, Vicky Y.
• dc.contributor.author Babarenda Gamage, Thiranja Prasad
• dc.contributor.author Pedrosa, João
• dc.contributor.author D’hooge, Jan
• dc.contributor.author Sutton, Timothy M.
• dc.contributor.author Lowe, Boris S.
• dc.contributor.author Legget, Malcolm E.
• dc.contributor.author Ruygrok, Peter N.
• dc.contributor.author Doughty, Robert N.
• dc.contributor.author Camara, Oscar
• dc.contributor.author Young, Alistair A.
• dc.contributor.author Nash, Martyn P.
• dc.date.accessioned 2023-03-21T07:05:48Z
• dc.date.available 2023-03-21T07:05:48Z
• dc.date.issued 2023
• dc.description.abstract Segmentation of the left ventricle (LV) in echocardiography is an important task for the quantification of volume and mass in heart disease. Continuing advances in echocardiography have extended imaging capabilities into the 3D domain, subsequently overcoming the geometric assumptions associated with conventional 2D acquisitions. Nevertheless, the analysis of 3D echocardiography (3DE) poses several challenges associated with limited spatial resolution, poor contrast-to-noise ratio, complex noise characteristics, and image anisotropy. To develop automated methods for 3DE analysis, a sufficiently large, labeled dataset is typically required. However, ground truth segmentations have historically been difficult to obtain due to the high inter-observer variability associated with manual analysis. We address this lack of expert consensus by registering labels derived from higher-resolution subject-specific cardiac magnetic resonance (CMR) images, producing 536 annotated 3DE images from 143 human subjects (10 of which were excluded). This heterogeneous population consists of healthy controls and patients with cardiac disease, across a range of demographics. To demonstrate the utility of such a dataset, a state-of-the-art, self-configuring deep learning network for semantic segmentation was employed for automated 3DE analysis. Using the proposed dataset for training, the network produced measurement biases of −9 ± 16 ml, −1 ± 10 ml, −2 ± 5 %, and 5 ± 23 g, for end-diastolic volume, end-systolic volume, ejection fraction, and mass, respectively, outperforming an expert human observer in terms of accuracy as well as scan-rescan reproducibility. As part of the Cardiac Atlas Project, we present here a large, publicly available 3DE dataset with ground truth labels that leverage the higher resolution and contrast of CMR, to provide a new benchmark for automated 3DE analysis. Such an approach not only reduces the effect of observer-specific bias present in manual 3DE annotations, but also enables the development of analysis techniques which exhibit better agreement with CMR compared to conventional methods. This represents an important step for enabling more efficient and accurate diagnostic and prognostic information to be obtained from echocardiography.
• dc.format.mimetype application/pdf
• dc.identifier.citation Zhao D, Ferdian E, Maso GD, Quill GM, Gilbert K, Wang VY, et al. MITEA: a dataset for machine learning segmentation of the left ventricle in 3D echocardiography using subject-specific labels from cardiac magnetic resonance imaging. Front Cardiovasc Med. 2023 Jan 10;9:1016703. DOI: 10.3389/fcvm.2022.1016703
• dc.identifier.doi http://dx.doi.org/10.3389/fcvm.2022.1016703
• dc.identifier.issn 2297-055X
• dc.identifier.uri http://hdl.handle.net/10230/56292
• dc.language.iso eng
• dc.publisher Frontiers
• dc.relation.ispartof Frontiers in Cardiovascular Medicine. 2023 Jan 10;9:1016703
• dc.rights © 2023 Zhao, Ferdian, Maso Talou, Quill, Gilbert, Wang, Babarenda Gamage, Pedrosa, D’hooge, Sutton, Lowe, Legget, Ruygrok, Doughty, Camara, Young and Nash. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword 3D echocardiography (3DE)
• dc.subject.keyword Machine learning (ML)
• dc.subject.keyword Segmentation (image processing)
• dc.subject.keyword Left ventricle (LV)
• dc.subject.keyword Multimodal imaging
• dc.subject.keyword Cardiac magnetic resonance (CMR) imaging
• dc.subject.keyword Domain adaptation
• dc.subject.keyword Cardiac Atlas Project
• dc.title MITEA: a dataset for machine learning segmentation of the left ventricle in 3D echocardiography using subject-specific labels from cardiac magnetic resonance imaging
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion