The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia: design, results and future prospects

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  • dc.contributor.author Middeldorp, Christel M.
  • dc.contributor.author Felix, Janine Frédérique
  • dc.contributor.author Mahajan, Anubha
  • dc.contributor.author EArly Genetics and Lifecourse Epidemiology (EAGLE) Consortium
  • dc.contributor.author Early Growth Genetics (EGG) Consortium
  • dc.contributor.author McCarthy, Mark I.
  • dc.date.accessioned 2019-07-02T10:02:26Z
  • dc.date.available 2019-07-02T10:02:26Z
  • dc.date.issued 2019
  • dc.description.abstract The impact of many unfavorable childhood traits or diseases, such as low birth weight and mental disorders, is not limited to childhood and adolescence, as they are also associated with poor outcomes in adulthood, such as cardiovascular disease. Insight into the genetic etiology of childhood and adolescent traits and disorders may therefore provide new perspectives, not only on how to improve wellbeing during childhood, but also how to prevent later adverse outcomes. To achieve the sample sizes required for genetic research, the Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia were established. The majority of the participating cohorts are longitudinal population-based samples, but other cohorts with data on early childhood phenotypes are also involved. Cohorts often have a broad focus and collect(ed) data on various somatic and psychiatric traits as well as environmental factors. Genetic variants have been successfully identified for multiple traits, for example, birth weight, atopic dermatitis, childhood BMI, allergic sensitization, and pubertal growth. Furthermore, the results have shown that genetic factors also partly underlie the association with adult traits. As sample sizes are still increasing, it is expected that future analyses will identify additional variants. This, in combination with the development of innovative statistical methods, will provide detailed insight on the mechanisms underlying the transition from childhood to adult disorders. Both consortia welcome new collaborations. Policies and contact details are available from the corresponding authors of this manuscript and/or the consortium websites.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Middeldorp CM, Felix JF, Mahajan A; EArly Genetics Lifecourse Epidemiology (EAGLE) consortium; Early Growth Genetics (EGG) consortium, McCarthy MI. The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia: design, results and future prospects. Eur J Epidemiol. 2019;34(3):279-300. DOI 10.1007/s10654-019-00502-9
  • dc.identifier.doi http://dx.doi.org/10.1007/s10654-019-00502-9
  • dc.identifier.issn 0393-2990
  • dc.identifier.uri http://hdl.handle.net/10230/41903
  • dc.language.iso eng
  • dc.publisher Springer
  • dc.relation.ispartof European Journal of Epidemiology. 2019;34(3):279-300
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/755320
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/742927
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/721567
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/633595
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/733206
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/294785
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/669545
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/261357
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/757919
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/268479
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/602768
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/308333
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/603794
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/634453
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/282957
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/201413
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/230374
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/295366
  • dc.rights © The Author(s) 2019. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licen ses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.keyword Childhood traits and disorders
  • dc.subject.keyword Consortium
  • dc.subject.keyword Genetics
  • dc.subject.keyword Longitudinal
  • dc.title The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia: design, results and future prospects
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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Articles (Departament de Medicina i Ciències de la Vida)
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