Brain correlates of urban environmental exposures in cognitively unimpaired individuals at increased risk for Alzheimer's disease: A study on Barcelona's population
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- dc.contributor.author Falcón, Carles
- dc.contributor.author Gascon Merlos, Mireia, 1984-
- dc.contributor.author Molinuevo, José Luis
- dc.contributor.author Operto, Grégory
- dc.contributor.author Cirach, Marta
- dc.contributor.author Gotsens, Xavier
- dc.contributor.author Fauria, Karine
- dc.contributor.author Arenaza Urquijo, Eider M.
- dc.contributor.author Pujol Martí, Jesús, 1981-
- dc.contributor.author Sunyer Deu, Jordi
- dc.contributor.author Nieuwenhuijsen, Mark J.
- dc.contributor.author Gispert López, Juan Domingo
- dc.contributor.author Crous-Bou, Marta
- dc.contributor.author ALFA Study
- dc.date.accessioned 2022-04-26T05:57:24Z
- dc.date.available 2022-04-26T05:57:24Z
- dc.date.issued 2021
- dc.description.abstract Introduction: Urban environmental exposures might contribute to the incidence of Alzheimer's disease (AD). Our aim was to identify structural brain imaging correlates of urban environmental exposures in cognitively unimpaired individuals at increased risk of AD. Methods: Two hundred twelve participants with brain scans and residing in Barcelona, Spain, were included. Land use regression models were used to estimate residential exposure to air pollutants. The daily average noise level was obtained from noise maps. Residential green exposure indicators were also generated. A cerebral 3D-T1 was acquired to obtain information on brain morphology. Voxel-based morphometry statistical analyses were conducted to determine the areas of the brain in which regional gray matter (GM) and white matter (WM) volumes were associated with environmental exposures. Results: Exposure to nitrogen dioxide was associated with lower GM volume in the precuneus and greater WM volume in the splenium of the corpus callosum and inferior longitudinal fasciculus. In contrast, exposure to fine particulate matter was associated with greater GM in cerebellum and WM in the splenium of corpus callosum, the superior longitudinal fasciculus, and cingulum cingulate gyrus. Noise was positively associated with WM volume in the body of the corpus callosum. Exposure to greenness was associated with greater GM volume in the middle frontal, precentral, and the temporal pole. Discussion: In cognitively unimpaired adults with increased risk of AD, exposure to air pollution, noise, and green areas are associated with GM and WM volumes of specific brain areas known to be affected in AD, thus potentially conferring a higher vulnerability to the disease.
- dc.format.mimetype application/pdf
- dc.identifier.citation Falcón C, Gascon M, Molinuevo JL, Operto G, Cirach M, Gotsens X, Fauria K, Arenaza-Urquijo EM, Pujol J, Sunyer J, Nieuwenhuijsen MJ, Gispert JD, Crous-Bou M. Brain correlates of urban environmental exposures in cognitively unimpaired individuals at increased risk for Alzheimer's disease: A study on Barcelona's population. Alzheimers Dement (Amst). 2021 Jul 5;13(1):e12205. DOI: 10.1002/dad2.12205
- dc.identifier.doi http://dx.doi.org/10.1002/dad2.12205
- dc.identifier.issn 2352-8729
- dc.identifier.uri http://hdl.handle.net/10230/52892
- dc.language.iso eng
- dc.publisher Wiley
- dc.relation.ispartof Alzheimers Dement (Amst). 2021 Jul 5;13(1):e12205
- dc.rights © 2021 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
- dc.subject.keyword Alzheimer's disease
- dc.subject.keyword Air pollution
- dc.subject.keyword Brain imaging
- dc.subject.keyword Greenness
- dc.subject.keyword Noise
- dc.subject.keyword Prevention
- dc.subject.keyword Risk factors
- dc.title Brain correlates of urban environmental exposures in cognitively unimpaired individuals at increased risk for Alzheimer's disease: A study on Barcelona's population
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion