Musculoskeletal senescence: a moving target ready to be eliminated

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dc.contributor.authorBaar, Marjolein P.ca
dc.contributor.authorPerdiguero, Eusebio, 1968-ca
dc.contributor.authorMuñoz Cánoves, Pura, 1962-ca
dc.contributor.authorde Keizer, Peter LJca
dc.date.accessioned2018-09-26T12:55:22Z
dc.date.available2018-09-26T12:55:22Z
dc.date.issued2018
dc.description.abstractAging is the prime risk factor for the broad-based development of diseases. Frailty is a phenotypical hallmark of aging and is often used to assess whether the predicted benefits of a therapy outweigh the risks for older patients. Senescent cells form as a consequence of unresolved molecular damage and persistently secrete molecules that can impair tissue function. Recent evidence shows senescent cells can chronically interfere with stem cell function and drive aging of the musculoskeletal system. In addition, targeted apoptosis of senescent cells can restore tissue homeostasis in aged animals. Thus, targeting cellular senescence provides new therapeutic opportunities for the intervention of frailty-associated pathologies and could have pleiotropic health benefits.
dc.description.sponsorshipThe authors acknowledge support for MB from Dutch Cancer Society Grant UMCU-7141 awarded to PdK, and for EP and PMC from ERC-2016-AdG-741966 (STEM-AGING), SAF2015-67369-R, MDA and AFM. The DCESX/UPF is recipient of a ‘María de Maeztu’ Program for Units of Excellence in R&D MDM-2014-0370 (Government of Spain)
dc.format.mimetypeapplication/pdf
dc.identifier.citationBaar MP, Perdiguero E, Muñoz-Cánoves P, de Keizer PL. Musculoskeletal senescence: a moving target ready to be eliminated. Curr Opin Pharmacol. 2018 Jun;40:147-55. DOI: 10.1016/j.coph.2018.05.007
dc.identifier.doihttp://dx.doi.org/10.1016/j.coph.2018.05.007
dc.identifier.issn1471-4892
dc.identifier.urihttp://hdl.handle.net/10230/35503
dc.language.isoeng
dc.publisherElsevierca
dc.relation.ispartofCurrent Opinion in Pharmacology. 2018 Jun;40:147-55
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/1PE/SAF2015-67369-R
dc.rights© 2018 Marjolein P. Baar, Eusebio Perdiguero, Pura Muñoz-Cánoves and Peter LJ de Keizer. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.otherEnvelliment
dc.subject.otherPersones grans dependents
dc.subject.otherAparell locomotor
dc.titleMusculoskeletal senescence: a moving target ready to be eliminatedca
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion

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