Musculoskeletal senescence: a moving target ready to be eliminated

Mostra el registre complet Registre parcial de l'ítem

• dc.contributor.author Baar, Marjolein P.ca
• dc.contributor.author Perdiguero, Eusebio, 1968-ca
• dc.contributor.author Muñoz Cánoves, Pura, 1962-ca
• dc.contributor.author de Keizer, Peter LJca
• dc.date.accessioned 2018-09-26T12:55:22Z
• dc.date.available 2018-09-26T12:55:22Z
• dc.date.issued 2018
• dc.description.abstract Aging is the prime risk factor for the broad-based development of diseases. Frailty is a phenotypical hallmark of aging and is often used to assess whether the predicted benefits of a therapy outweigh the risks for older patients. Senescent cells form as a consequence of unresolved molecular damage and persistently secrete molecules that can impair tissue function. Recent evidence shows senescent cells can chronically interfere with stem cell function and drive aging of the musculoskeletal system. In addition, targeted apoptosis of senescent cells can restore tissue homeostasis in aged animals. Thus, targeting cellular senescence provides new therapeutic opportunities for the intervention of frailty-associated pathologies and could have pleiotropic health benefits.
• dc.description.sponsorship The authors acknowledge support for MB from Dutch Cancer Society Grant UMCU-7141 awarded to PdK, and for EP and PMC from ERC-2016-AdG-741966 (STEM-AGING), SAF2015-67369-R, MDA and AFM. The DCESX/UPF is recipient of a ‘María de Maeztu’ Program for Units of Excellence in R&D MDM-2014-0370 (Government of Spain)
• dc.format.mimetype application/pdf
• dc.identifier.citation Baar MP, Perdiguero E, Muñoz-Cánoves P, de Keizer PL. Musculoskeletal senescence: a moving target ready to be eliminated. Curr Opin Pharmacol. 2018 Jun;40:147-55. DOI: 10.1016/j.coph.2018.05.007
• dc.identifier.doi http://dx.doi.org/10.1016/j.coph.2018.05.007
• dc.identifier.issn 1471-4892
• dc.identifier.uri http://hdl.handle.net/10230/35503
• dc.language.iso eng
• dc.publisher Elsevierca
• dc.relation.ispartof Current Opinion in Pharmacology. 2018 Jun;40:147-55
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/SAF2015-67369-R
• dc.rights © 2018 Marjolein P. Baar, Eusebio Perdiguero, Pura Muñoz-Cánoves and Peter LJ de Keizer. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.other Envelliment
• dc.subject.other Persones grans dependents
• dc.subject.other Aparell locomotor
• dc.title Musculoskeletal senescence: a moving target ready to be eliminatedca
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion