A Synthetic Strategy for Conjugation of Paromomycin to Cell-Penetrating Tat(48-60) for Delivery and Visualization into Leishmania Parasites
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- dc.contributor.author Defaus, Siraca
- dc.contributor.author Gallo, María, 1989-ca
- dc.contributor.author Abengózar, María Ángelesca
- dc.contributor.author Rivas, Luisca
- dc.contributor.author Andreu Martínez, Davidca
- dc.date.accessioned 2017-05-26T07:52:46Z
- dc.date.available 2017-05-26T07:52:46Z
- dc.date.issued 2017
- dc.description.abstract A successful approach to deliver paromomycin, a poorly absorbed aminoglycoside antibiotic, to parasite cells is reported, based on selective protection of amino and hydroxyl groups followed by conjugation to a fluorolabeled, PEG-functionalized cell-penetrating Tat(48-60) peptide. The resulting construct is efficiently internalized into Leishmania cells, evidencing the fitness of cell-penetrating peptides as vectors for efficiently transporting low-bioavailability drugs into cells.
- dc.description.sponsorship Work at Pompeu Fabra University was supported by Grants SAF2011-24899 and AGL2014-52395-C2-2-R from the Spanish Ministry of Economy and Competiveness (MINECO) to David Andreu; work at the Centro de Investigaciones Biológicas was supported by Grants PI12-02706 from ISCIII-FEDER, SAF2015-65740-R from MINECO to Luis Rivas, and RICET RD12/0018/0007 and RD16/0027/0010-FEDER.
- dc.format.mimetype application/pdfca
- dc.identifier.citation Defaus S, Gallo M, Abengózar MA, Rivas L, Andreu Martínez D. A Synthetic Strategy for Conjugation of Paromomycin to Cell-Penetrating Tat(48-60) for Delivery and Visualization into Leishmania Parasites. International Journal of Peptides. 2017;2017:4213037. DOI: 10.1155/2017/4213037
- dc.identifier.doi http://dx.doi.org/10.1155/2017/4213037
- dc.identifier.uri http://hdl.handle.net/10230/32170
- dc.language.iso eng
- dc.publisher Hindawica
- dc.relation.ispartof International Journal of Peptides. 2017;2017:4213037
- dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2011-24899
- dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/AGL2014-52395-C2-2-R
- dc.rights Copyright © 2017 Sira Defaus et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri https://creativecommons.org/licenses/by/4.0/
- dc.title A Synthetic Strategy for Conjugation of Paromomycin to Cell-Penetrating Tat(48-60) for Delivery and Visualization into Leishmania Parasitesca
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion