A Synthetic Strategy for Conjugation of Paromomycin to Cell-Penetrating Tat(48-60) for Delivery and Visualization into Leishmania Parasites

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dc.contributor.authorDefaus, Siraca
dc.contributor.authorGallo, María, 1989-ca
dc.contributor.authorAbengózar, María Ángelesca
dc.contributor.authorRivas, Luisca
dc.contributor.authorAndreu Martínez, Davidca
dc.date.accessioned2017-05-26T07:52:46Z
dc.date.available2017-05-26T07:52:46Z
dc.date.issued2017
dc.description.abstractA successful approach to deliver paromomycin, a poorly absorbed aminoglycoside antibiotic, to parasite cells is reported, based on selective protection of amino and hydroxyl groups followed by conjugation to a fluorolabeled, PEG-functionalized cell-penetrating Tat(48-60) peptide. The resulting construct is efficiently internalized into Leishmania cells, evidencing the fitness of cell-penetrating peptides as vectors for efficiently transporting low-bioavailability drugs into cells.
dc.description.sponsorshipWork at Pompeu Fabra University was supported by Grants SAF2011-24899 and AGL2014-52395-C2-2-R from the Spanish Ministry of Economy and Competiveness (MINECO) to David Andreu; work at the Centro de Investigaciones Biológicas was supported by Grants PI12-02706 from ISCIII-FEDER, SAF2015-65740-R from MINECO to Luis Rivas, and RICET RD12/0018/0007 and RD16/0027/0010-FEDER.
dc.format.mimetypeapplication/pdfca
dc.identifier.citationDefaus S, Gallo M, Abengózar MA, Rivas L, Andreu Martínez D. A Synthetic Strategy for Conjugation of Paromomycin to Cell-Penetrating Tat(48-60) for Delivery and Visualization into Leishmania Parasites. International Journal of Peptides. 2017;2017:4213037. DOI: 10.1155/2017/4213037
dc.identifier.doihttp://dx.doi.org/10.1155/2017/4213037
dc.identifier.urihttp://hdl.handle.net/10230/32170
dc.language.isoeng
dc.publisherHindawica
dc.relation.ispartofInternational Journal of Peptides. 2017;2017:4213037
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/3PN/SAF2011-24899
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/1PE/AGL2014-52395-C2-2-R
dc.rightsCopyright © 2017 Sira Defaus et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleA Synthetic Strategy for Conjugation of Paromomycin to Cell-Penetrating Tat(48-60) for Delivery and Visualization into Leishmania Parasitesca
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion

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