A method for small-animal PET/CT alignment calibration. Physics in medicine & biology

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• dc.contributor.author Pascau, Javierca
• dc.contributor.author Vaquero, Juan J.ca
• dc.contributor.author Chamorro Servent, Juditca
• dc.contributor.author Rodríguez-Ruano, A.ca
• dc.contributor.author Desco, Manuelca
• dc.date.accessioned 2018-05-09T17:27:22Z
• dc.date.available 2018-05-09T17:27:22Z
• dc.date.issued 2012
• dc.description.abstract Small-animal positron-emission tomography/computed tomography (PET/ CT) scanners provide anatomical and molecular imaging, which enables the joint visualization and analysis of both types of data. A proper alignment calibration procedure is essential for small-animal imaging since resolution is much higher than that in human devices. This work presents an alignment phantom and two different calibration methods that provide a reliable and repeatable measurement of the spatial geometrical alignment between the PET and the CT subsystems of a hybrid scanner. The phantom can be built using laboratory materials, and it is meant to estimate the rigid spatial transformation that aligns both modalities. It consists of three glass capillaries filled with a positron-emitter solution and positioned in a non-coplanar triangular geometry inside the system field of view. The calibration methods proposed are both based on automatic line detection, but with different approaches to calculate the transformation of the lines between both modalities. Our results show an average accuracy of the alignment estimation of 0.39 mm over the whole field of view.en
• dc.description.sponsorship This study was funded by CDTI under the CENIT Program (AMIT Project), projects ARTEMIS S2009/DPI-1802 (CAM) and TEC2010-21619-C04-01, and supported by the Spanish Ministry of Economy and Competitiveness.en
• dc.format.mimetype application/pdf
• dc.identifier.citation Pascau J, Vaquero JJ, Chamorro-Servent J, Rodríguez Ruano A, Desco M . A method for small-animal PET/CT alignment calibration. Physics in medicine & biology. 2012;57(12):199-207. DOI: 10.1088/0031-9155/57/12/N199
• dc.identifier.doi http://dx.doi.org/10.1088/0031-9155/57/12/N199
• dc.identifier.issn 0031-9155
• dc.identifier.uri http://hdl.handle.net/10230/34604
• dc.language.iso eng
• dc.publisher Institute of Physics (IOP)ca
• dc.relation.ispartof Physics in medicine & biology. 2012;57(12):199-207
• dc.rights © Institute of Physics (IOP) http://dx.doi.org/10.1088/0031-9155/57/12/N199
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.title A method for small-animal PET/CT alignment calibration. Physics in medicine & biologyca
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion