Osteoarticular cryptococcosis successfully treated with high-dose liposomal amphotericin B followed by oral fluconazole
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- dc.contributor.author Deus, Guillem
- dc.contributor.author Gómez-Zorrilla, Silvia
- dc.contributor.author Echeverría Esnal, Daniel
- dc.contributor.author Siverio-Parès, Ana
- dc.contributor.author Güerri Fernández, Roberto
- dc.contributor.author Ares, Jesús
- dc.contributor.author Campillo Ambrós, Núria
- dc.contributor.author Letang Jiménez de Anta, Emilio Ángel
- dc.contributor.author Knobel Freud, Hernando
- dc.contributor.author Grau Cerrato, Santiago
- dc.contributor.author Horcajada Gallego, Juan Pablo
- dc.date.accessioned 2021-06-18T06:31:40Z
- dc.date.available 2021-06-18T06:31:40Z
- dc.date.issued 2021
- dc.description.abstract Background: Skeletal involvement of Cryptococcus neoformans is infrequent and usually associated with disseminated cryptococcosis or underlying predisposing conditions. We present an atypical case of osteoarticular cryptococcosis in an immunocompetent patient. Case presentation: We herein report a case of bone and soft tissue cryptococcal infection in a 42-year-old male from Pakistan with well-controlled diabetes without other associated immunodeficiencies treated with antifungal therapy without surgical debridement. Furthermore, the patient developed toxidermia due to fluconazole use, so a fluconazole desensitization was performed. Therapeutic management also included the performance of therapeutic drug monitoring of fluconazole plasma concentrations. Conclusion: To our knowledge, this is the first case of osteoarticular cryptococcosis treated with this treatment regimen. This strategy may be of interest to try to reduce hospital stay and associated complications.
- dc.format.mimetype application/pdf
- dc.identifier.citation Deus G, Gómez-Zorrilla S, Echeverria-Esnal D, Siverio A, Güerri-Fernandez R, Ares J, Campillo N, Letang E, Knobel H, Grau S, Horcajada JP. Osteoarticular cryptococcosis successfully treated with high-dose liposomal amphotericin B followed by oral fluconazole. Infect Drug Resist. 2021;14:719-22. DOI: 10.2147/IDR.S294299
- dc.identifier.doi http://dx.doi.org/10.2147/IDR.S294299
- dc.identifier.issn 1178-6973
- dc.identifier.uri http://hdl.handle.net/10230/47929
- dc.language.iso eng
- dc.publisher Dove Medical Press
- dc.relation.ispartof Infect Drug Resist. 2021;14:719-22
- dc.rights © 2021 Deus et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri https://creativecommons.org/licenses/by-nc/3.0/
- dc.subject.keyword Cryptococcus neoformans
- dc.subject.keyword Fluconazole desensitization
- dc.subject.keyword Immunocompetent
- dc.subject.keyword Liposomal amphotericin B
- dc.subject.keyword Osteoarticular cryptococcosis
- dc.title Osteoarticular cryptococcosis successfully treated with high-dose liposomal amphotericin B followed by oral fluconazole
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion