Human Early Life Exposome (HELIX) study: a European population-based exposome cohort

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• dc.contributor.author Maitre, Léa
• dc.contributor.author De Bont, Jeroen, 1989-
• dc.contributor.author Casas Sanahuja, Maribel
• dc.contributor.author Robinson, Oliver
• dc.contributor.author Basagaña Flores, Xavier
• dc.contributor.author Borràs, Eva
• dc.contributor.author Bustamante Pineda, Mariona
• dc.contributor.author de Castro, Montserrat
• dc.contributor.author Donaire González, David
• dc.contributor.author Estivill, Xavier, 1955-
• dc.contributor.author Fossati, Serena
• dc.contributor.author González, Juan Ramón
• dc.contributor.author Hernández-Ferrer, Carles
• dc.contributor.author Júlvez Calvo, Jordi
• dc.contributor.author Manzano Salgado, Cyntia Beatriz, 1987-
• dc.contributor.author Sabidó Aguadé, Eduard, 1981-
• dc.contributor.author Sunyer Deu, Jordi
• dc.contributor.author Tamayo-Uria, Ibon
• dc.contributor.author Urquiza, José M.
• dc.contributor.author van Gent, Diana
• dc.contributor.author Vives Usano, Marta, 1990-
• dc.contributor.author Warembourg, Charline
• dc.contributor.author Nieuwenhuijsen, Mark J.
• dc.contributor.author Vrijheid, Martine
• dc.date.accessioned 2019-03-18T08:37:09Z
• dc.date.available 2019-03-18T08:37:09Z
• dc.date.issued 2018
• dc.description.abstract PURPOSE: Essential to exposome research is the collection of data on many environmental exposures from different domains in the same subjects. The aim of the Human Early Life Exposome (HELIX) study was to measure and describe multiple environmental exposures during early life (pregnancy and childhood) in a prospective cohort and associate these exposures with molecular omics signatures and child health outcomes. Here, we describe recruitment, measurements available and baseline data of the HELIX study populations. PARTICIPANTS: The HELIX study represents a collaborative project across six established and ongoing longitudinal population-based birth cohort studies in six European countries (France, Greece, Lithuania, Norway, Spain and the UK). HELIX used a multilevel study design with the entire study population totalling 31 472 mother-child pairs, recruited during pregnancy, in the six existing cohorts (first level); a subcohort of 1301 mother-child pairs where biomarkers, omics signatures and child health outcomes were measured at age 6-11 years (second level) and repeat-sampling panel studies with around 150 children and 150 pregnant women aimed at collecting personal exposure data (third level). FINDINGS TO DATE: Cohort data include urban environment, hazardous substances and lifestyle-related exposures for women during pregnancy and their offspring from birth until 6-11 years. Common, standardised protocols were used to collect biological samples, measure exposure biomarkers and omics signatures and assess child health across the six cohorts. Baseline data of the cohort show substantial variation in health outcomes and determinants between the six countries, for example, in family affluence levels, tobacco smoking, physical activity, dietary habits and prevalence of childhood obesity, asthma, allergies and attention deficit hyperactivity disorder. FUTURE PLANS: HELIX study results will inform on the early life exposome and its association with molecular omics signatures and child health outcomes. Cohort data are accessible for future research involving researchers external to the project.
• dc.description.sponsorship The research leading to these results has received funding from the European Community’s Seventh Framework Programme (FP7/2007-206) under grant agreement no 308333—the HELIX project. Dr Maribel Casas and Dr Jordi Julvez received funding from Instituto de Salud Carlos III (Ministry of Economy and Competitiveness) (MS16/00128, MS14/00108). INMA data collections were supported by grants from the Instituto de Salud Carlos III, CIBERESP, the Conselleria de Sanitat, Generalitat Valenciana, Department of Health of the Basque Government; the Provincial Government of Gipuzkoa, and the Generalitat de Catalunya-CIRIT. KANC was funded by the grant of the Lithuanian Agency for Science Innovation and Technology (6-04-2014_31V-66). The Norwegian Mother and Child Cohort Study (MoBa) is supported by the Norwegian Ministry of Health and the Ministry of Education and Research, NIH/NIEHS (contract no. N01-ES-75558), and NIH/NINDS (grant no. 1 UO1 NS 047537-01 and grant no. 2 UO1 NS 047537-06A1). The Rhea project was financially supported by European projects, and the Greek Ministry of Health (Program of Prevention of Obesity and Neurodevelopmental Disorders in Preschool Children, in Heraklion district, Crete, Greece: 2011–2014; 'Rhea Plus': Primary Prevention Program of Environmental Risk Factors for Reproductive Health, and Child Health: 2012–2015). The work was also supported by MICINN (MTM2015-68140-R) and Centro Nacional de Genotipado-CEGEN-PRB2-ISCIII. CW received funding from the Fondation de France.
• dc.format.mimetype application/pdf
• dc.identifier.citation Maitre L, de Bont J, Casas M, Robinson O, Aasvang GM, Agier L. et al. Human Early Life Exposome (HELIX) study: a European population-based exposome cohort. BMJ Open. 2018 Sep 10;8(9):e021311. DOI: 10.1136/bmjopen-2017-021311
• dc.identifier.doi http://dx.doi.org/10.1136/bmjopen-2017-021311
• dc.identifier.issn 2044-6055
• dc.identifier.uri http://hdl.handle.net/10230/36848
• dc.language.iso eng
• dc.publisher BMJ Publishing Group
• dc.relation.ispartof BMJ Open. 2018 Sep 10;8(9):e021311
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/308333
• dc.rights Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
• dc.subject.keyword Birth cohort
• dc.subject.keyword Community child health
• dc.subject.keyword Epidemiology
• dc.subject.keyword Exposome
• dc.subject.keyword Omics
• dc.subject.keyword Public health
• dc.subject.other Exposoma
• dc.subject.other Salut Pública
• dc.title Human Early Life Exposome (HELIX) study: a European population-based exposome cohort
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion