Comparison of surgical risk scores in a european cohort of patients with advanced chronic liver disease

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• dc.contributor.author Canillas, Lidia
• dc.contributor.author Pelegrina Manzano, Amalia
• dc.contributor.author Colominas-González, Elena
• dc.contributor.author Salis, Aina
• dc.contributor.author Enríquez Rodríguez, César Jessé
• dc.contributor.author Duran Jordà, Xavier, 1974-
• dc.contributor.author Caro, Antonia
• dc.contributor.author Álvarez, Juan C.
• dc.contributor.author Carrión Rodríguez, José Antonio
• dc.date.accessioned 2024-10-23T06:09:24Z
• dc.date.available 2024-10-23T06:09:24Z
• dc.date.issued 2023
• dc.description.abstract Patients with advanced chronic liver disease (ACLD) or cirrhosis undergoing surgery have an increased risk of morbidity and mortality in contrast to the general population. This is a retrospective, observational study to evaluate the predictive capacity of surgical risk scores in European patients with ACLD. Cirrhosis was defined by the presence of thrombocytopenia with <150,000/uL and splenomegaly, and AST-to-Platelet Ratio Index >2, a nodular liver edge seen via ultrasound, transient elastography of >15 kPa, and/or signs of portal hypertension. We assessed variables related to 90-day mortality and the discrimination and calibration of current surgical scores (Child-Pugh, MELD-Na, MRS, NSQIP, and VOCAL-Penn). Only patients with ACLD and major surgeries included in VOCAL-Penn were considered (n = 512). The mortality rate at 90 days after surgery was 9.8%. Baseline disparities between the H. Mar and VOCAL-Penn cohorts were identified. Etiology, obesity, and platelet count were not associated with mortality. The VOCAL-Penn showed the best discrimination (C-statistic90D = 0.876) and overall predictive capacity (Brier90D = 0.054), but calibration was not excellent in our cohort. VOCAL-Penn was suboptimal in patients with diabetes (C-statistic30D = 0.770), without signs of portal hypertension (C-statistic30D = 0.555), or with abdominal wall (C-statistic30D = 0.608) or urgent (C-statistic180D = 0.692) surgeries. Our European cohort has shown a mortality rate after surgery similar to those described in American studies. However, some variables included in the VOCAL-Penn score were not associated with mortality, and VOCAL-Penn's discriminative ability decreases in patients with diabetes, without signs of portal hypertension, and with abdominal wall or urgent surgeries. These results should be validated in larger multicenter and prospective studies.
• dc.format.mimetype application/pdf
• dc.identifier.citation Canillas L, Pelegrina A, Colominas-González E, Salis A, Enríquez-Rodríguez CJ, Duran X, et al. Comparison of surgical risk scores in a european cohort of patients with advanced chronic liver disease. J Clin Med. 2023 Sep 21;12(18):6100. DOI: 10.3390/jcm12186100
• dc.identifier.doi http://dx.doi.org/10.3390/jcm12186100
• dc.identifier.issn 2077-0383
• dc.identifier.uri http://hdl.handle.net/10230/68318
• dc.language.iso eng
• dc.publisher MDPI
• dc.relation.ispartof J Clin Med. 2023 Sep 21;12(18):6100
• dc.rights © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Advanced chronic liver disease
• dc.subject.keyword Cirrhosis
• dc.subject.keyword Mortality
• dc.subject.keyword Postoperative risk
• dc.subject.keyword Surgery
• dc.title Comparison of surgical risk scores in a european cohort of patients with advanced chronic liver disease
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion