Identity noise and adipogenic traits characterize dermal fibroblast aging
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- dc.contributor.author Aznar Benitah, Salvador
- dc.contributor.author Lafzi, Atefeh
- dc.contributor.author Berenguer-Llergo, Antonio
- dc.contributor.author Youssif, Catrin
- dc.contributor.author Castellanos, Andrés
- dc.contributor.author Solanas, Guiomar
- dc.contributor.author Peixoto, Francisca Oliveira
- dc.contributor.author Stephan-Otto Attolini, Camille
- dc.contributor.author Prats, Neus
- dc.contributor.author Aguilera, Mònica
- dc.contributor.author Martín Caballero, Juan
- dc.contributor.author Heyn, Holger
- dc.contributor.author Aznar Benitah, Salvador
- dc.date.accessioned 2019-02-28T09:32:03Z
- dc.date.issued 2018
- dc.description.abstract During aging, stromal functions are thought to be impaired, but little is known whether this stems from changes of fibroblasts. Using population- and single-cell transcriptomics, as well as long-term lineage tracing, we studied whether murine dermal fibroblasts are altered during physiological aging under different dietary regimes that affect longevity. We show that the identity of old fibroblasts becomes undefined, with the fibroblast states present in young skin no longer clearly demarcated. In addition, old fibroblasts not only reduce the expression of genes involved in the formation of the extracellular matrix, but also gain adipogenic traits, paradoxically becoming more similar to neonatal pro-adipogenic fibroblasts. These alterations are sensitive to systemic metabolic changes: long-term caloric restriction reversibly prevents them, whereas a high-fat diet potentiates them. Our results therefore highlight loss of cell identity and the acquisition of adipogenic traits as a mechanism underlying cellular aging, which is influenced by systemic metabolism.
- dc.description.sponsorship M.C.S. was supported by a Boehringer Ingelheim Fonds International PhD fellowship. IRB Barcelona is the recipient of a Severo Ochoa Award of Excellence from MINECO (Government of Spain). H.H. is a Miguel Servet (CP14/00229) researcher funded by the Spanish Institute of Health Carlos III (ISCIII). This work has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Sk1odowska-Curie grant agreement No. H2020-MSCA-ITN-2015-675752 (SINGEK)
- dc.format.mimetype application/pdf
- dc.identifier.citation Salzer MC, Lafzi A, Berenguer-Llergo A, Youssif C, Castellanos A, Solanas G et al. Identity noise and adipogenic traits characterize dermal fibroblast aging. Cell. 2018 Nov 29;175(6):1575-90.e22. DOI: 10.1016/j.cell.2018.10.012
- dc.identifier.doi http://dx.doi.org/10.1016/j.cell.2018.10.012
- dc.identifier.issn 0092-8674
- dc.identifier.uri http://hdl.handle.net/10230/36697
- dc.language.iso eng
- dc.publisher Elsevier
- dc.relation.ispartof Cell. 2018 Nov 29;175(6):1575-90.e22
- dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/675752
- dc.rights © Elsevier http://dx.doi.org/10.1016/j.cell.2018.10.012
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.subject.other Diferenciació cel·lular
- dc.subject.other Envelliment
- dc.subject.other Dermatologia
- dc.subject.other Fibroblasts
- dc.title Identity noise and adipogenic traits characterize dermal fibroblast aging
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/acceptedVersion