Cancer differentiation therapy dynamics in a hybrid model of avascular tumor growth
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- dc.contributor.author Borràs Sánchez, Marc
- dc.date.accessioned 2022-11-04T17:50:04Z
- dc.date.available 2022-11-04T17:50:04Z
- dc.date.issued 2022
- dc.description Tutor: Ricard Solé Vicente
- dc.description Treball de fi de grau en Biomèdica
- dc.description.abstract Cancer is not one disease but many, making it very difficult to successfully develop treatments that effectively end it. Yet, a very promising approach still underde- veloped is differentiation therapy (DTH). As it has long been demonstrated, most tumors are conformed by a cell population a great part of which is poorly differ- entiated, exhibiting a loss of communication and tissue homeostasis among other things. As a result, they can achieve several hallmarks essential to their identity and chances of success. DTH has been proposed to be an efficient therapy and can be combined with cytotoxic-based therapies, and successfully used as a treatment for acute promyelocytic leukemia (APL). However, DTH has failed so far when deal- ing with solid tumors. Why? It has been suggested that the high degree of spatial intra-tumoral heterogeneity combined with the resilience of CSCs and their capa- bility to repopulate tumors by themselves might act as a firewall to DTH drugs. In order to test this possibility and assess the effects of DTH on solid tumors, we pro- pose a mathematical and computational study of DTH using a spatially extended avascular tumor model. The results obtained support the previous hypothesis and indirect evidence concerning the role of space and cancer tissue architecture.ca
- dc.format.mimetype application/pdf*
- dc.identifier.uri http://hdl.handle.net/10230/54698
- dc.language.iso engca
- dc.rights ©Tots els drets reservatsca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.subject.keyword Cancer
- dc.subject.keyword Differentiation therapy
- dc.subject.keyword Competition
- dc.subject.keyword Ecology
- dc.subject.keyword Habitat fragmentation
- dc.subject.keyword Cancer stem cells
- dc.subject.keyword Complex systems
- dc.title Cancer differentiation therapy dynamics in a hybrid model of avascular tumor growthca
- dc.type info:eu-repo/semantics/bachelorThesisca