Cancer differentiation therapy dynamics in a hybrid model of avascular tumor growth

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  • dc.contributor.author Borràs Sánchez, Marc
  • dc.date.accessioned 2022-11-04T17:50:04Z
  • dc.date.available 2022-11-04T17:50:04Z
  • dc.date.issued 2022
  • dc.description Tutor: Ricard Solé Vicente
  • dc.description Treball de fi de grau en Biomèdica
  • dc.description.abstract Cancer is not one disease but many, making it very difficult to successfully develop treatments that effectively end it. Yet, a very promising approach still underde- veloped is differentiation therapy (DTH). As it has long been demonstrated, most tumors are conformed by a cell population a great part of which is poorly differ- entiated, exhibiting a loss of communication and tissue homeostasis among other things. As a result, they can achieve several hallmarks essential to their identity and chances of success. DTH has been proposed to be an efficient therapy and can be combined with cytotoxic-based therapies, and successfully used as a treatment for acute promyelocytic leukemia (APL). However, DTH has failed so far when deal- ing with solid tumors. Why? It has been suggested that the high degree of spatial intra-tumoral heterogeneity combined with the resilience of CSCs and their capa- bility to repopulate tumors by themselves might act as a firewall to DTH drugs. In order to test this possibility and assess the effects of DTH on solid tumors, we pro- pose a mathematical and computational study of DTH using a spatially extended avascular tumor model. The results obtained support the previous hypothesis and indirect evidence concerning the role of space and cancer tissue architecture.ca
  • dc.format.mimetype application/pdf*
  • dc.identifier.uri http://hdl.handle.net/10230/54698
  • dc.language.iso engca
  • dc.rights ©Tots els drets reservatsca
  • dc.rights.accessRights info:eu-repo/semantics/openAccessca
  • dc.subject.keyword Cancer
  • dc.subject.keyword Differentiation therapy
  • dc.subject.keyword Competition
  • dc.subject.keyword Ecology
  • dc.subject.keyword Habitat fragmentation
  • dc.subject.keyword Cancer stem cells
  • dc.subject.keyword Complex systems
  • dc.title Cancer differentiation therapy dynamics in a hybrid model of avascular tumor growthca
  • dc.type info:eu-repo/semantics/bachelorThesisca