Association between long-term exposure to traffic-related air pollution and subclinical atherosclerosis: the REGICOR study

Mostra el registre complet Registre parcial de l'ítem

  • dc.contributor.author Rivera, Marcela, 1982-
  • dc.contributor.author Basagaña Flores, Xavier
  • dc.contributor.author Aguilera Jiménez, Inmaculada, 1977-
  • dc.contributor.author Foraster Pulido, Maria, 1984-
  • dc.contributor.author Agis, David
  • dc.contributor.author Groot, Eric de
  • dc.contributor.author Pérez Grau, Laura
  • dc.contributor.author Mendez, Michelle A.
  • dc.contributor.author Bouso, Laura
  • dc.contributor.author Targa, Jaume
  • dc.contributor.author Ramos, Rafel
  • dc.contributor.author Sala, Joan
  • dc.contributor.author Marrugat de la Iglesia, Jaume
  • dc.contributor.author Elosua Llanos, Roberto
  • dc.contributor.author Künzli, Nino
  • dc.date.accessioned 2019-07-10T07:23:31Z
  • dc.date.available 2019-07-10T07:23:31Z
  • dc.date.issued 2013
  • dc.description.abstract BACKGROUND: Epidemiological evidence of the effects of long-term exposure to air pollution on the chronic processes of atherogenesis is limited. OBJECTIVE: We investigated the association of long-term exposure to traffic-related air pollution with subclinical atherosclerosis, measured by carotid intima media thickness (IMT) and ankle-brachial index (ABI). METHODS: We performed a cross-sectional analysis using data collected during the reexamination (2007-2010) of 2,780 participants in the REGICOR (Registre Gironí del Cor: the Gerona Heart Register) study, a population-based prospective cohort in Girona, Spain. Long-term exposure across residences was calculated as the last 10 years' time-weighted average of residential nitrogen dioxide (NO2) estimates (based on a local-scale land-use regression model), traffic intensity in the nearest street, and traffic intensity in a 100 m buffer. Associations with IMT and ABI were estimated using linear regression and multinomial logistic regression, respectively, controlling for sex, age, smoking status, education, marital status, and several other potential confounders or intermediates. RESULTS: Exposure contrasts between the 5th and 95th percentiles for NO2 (25 µg/m3), traffic intensity in the nearest street (15,000 vehicles/day), and traffic load within 100 m (7,200,000 vehicle-m/day) were associated with differences of 0.56% (95% CI: -1.5, 2.6%), 2.32% (95% CI: 0.48, 4.17%), and 1.91% (95% CI: -0.24, 4.06) percent difference in IMT, respectively. Exposures were positively associated with an ABI of > 1.3, but not an ABI of < 0.9. Stronger associations were observed among those with a high level of education and in men ≥ 60 years of age. CONCLUSIONS: Long-term traffic-related exposures were associated with subclinical markers of atherosclerosis. Prospective studies are needed to confirm associations and further examine differences among population subgroups.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Rivera M, Basagaña Flores X, Aguilera I, Foraster M, Agis D, de Groot E et al. Association between long-term exposure to traffic-related air pollution and subclinical atherosclerosis: the REGICOR study. Environ Health Perspect. 2013 Feb;121(2):223-30. DOI: 10.1289/ehp.1205146
  • dc.identifier.doi http://dx.doi.org/10.1289/ehp.1205146
  • dc.identifier.issn 0091-6765
  • dc.identifier.uri http://hdl.handle.net/10230/41969
  • dc.language.iso eng
  • dc.publisher National Institute of Environmental Health Sciences (NIEHS)
  • dc.relation.ispartof Environmental Health Perspectives. 2013 Feb;121(2):223-30
  • dc.rights Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, "Reproduced with permission from Environmental Health Perspectives"); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.subject.other Aire -- Contaminació
  • dc.subject.other Aterosclerosi
  • dc.subject.other Automòbils -- Aspectes ambientals
  • dc.title Association between long-term exposure to traffic-related air pollution and subclinical atherosclerosis: the REGICOR study
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

Col·leccions

Articles (Departament de Medicina i Ciències de la Vida)
Articles (Barcelona Institute for Global Health (ISGlobal) – Campus Mar)
Articles (Hospital del Mar Research Institute)